Advances in the value of anti-Müllerian hormone in the diagnosis of polycystic ovary syndrome

doi:10.3877/cma.j.issn.2095-655X.2021.04.015

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects the physical and reproductive health of women.The main diagnostic criteria of PCOS are sparse menstruation, amenorrhea or irregular uterine bleeding, clinical manifestation of hyperandrogen or hyperandrogenemia, and polycystic ovary change.In clinical practice, the traditional diagnostic methods have some limitations, so it is urgent to introduce new auxiliary diagnostic indicators. Recent studies have shown that anti-Müllerian hormone (AMH) is closely related to the pathophysiological development of PCOS, and it is closely related to follicular development and endocrine hormone levels. As a new biochemical index for the diagnosis of PCOS, AMH shows many advantages. Conventional hormone detection combined with AMH detection has important reference value for the diagnosis and evaluation of PCOS. In this paper, the research progress of AMH on the diagnostic value of PCOS is reviewed.

Key words: Anti-Müllerian hormone, Polycystic ovary syndrome, Diagnosis

Lele Bai, Xiaoxi Zhao. Advances in the value of anti-Müllerian hormone in the diagnosis of polycystic ovary syndrome[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(04): 282-284.

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References 29

[1]	Fauser BC, Tarlatzis BC, Rebar RW，et al.Consensus on women′s health aspects of polycystic ovary syndrome(PCOS)：the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J]．Fertil Steril，2012，97(1)：28-38.
[2]	谢幸，孔北华，段涛．妇产科学[M].9版．北京：人民卫生出版社，2018：348-350.
[3]	陶弢，王丽华．多囊卵巢综合征诊治内分泌专家共识[J]．中华内分泌代谢杂志，2018，34(1)：1-7.
[4]	Deswal R, Yadav A, Dang AS. Sex hormone binding globulin-an important biomarker for predicting PCOS risk：a systematic review and meta-analysis[J]．Syst Biol Reprod Med，2018，64(1)：12-24.
[5]	Lie Fong S, Visser JA, Welt CK, et al. Serum anti-müllerian hormone levels in healthy females：a nomogram ranging from infancy to adulthood[J]．J Clin Endocrinol Metab，2012，97(12)：4650-4655.
[6]	Durlinger AL, Gruijters MJ, Kramer P, et al. Anti-Müllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary[J]．Endocrinology，2001，142(11)：4891-4899.
[7]	Dumont A, Robin G, Catteau-Jonard S，et al.Role of anti-Müllerian hormone in pathophysiology，diagnosis and treatment ofpolycystic ovary syndrome：a review[J]．Reprod Biol Endocrinol，2015(13)：137.
[8]	贺侠琴，孙桂荣，王汝琨，等．血清抗缪勒管激素与性激素联合检测对多囊卵巢综合征的诊断价值[J]．中华检验医学杂志，2018，41(6)：456-461.
[9]	Gorsic LK, Kosova G, Werstein B，et al.Pathogenic anti-müllerian hormone variants in polycystic ovary syndrome[J]．J Clin Endocrinol Metab，2017，102(8)：2862-2872.
[10]	Racine C, Genêt C, Bourgneuf C, et al. New anti-Müllerian hormone target genes involved in granulosa cell survival in women with polycystic ovary syndrome [J]．J Clin Endocrinol Metab，2020(28)：dgaa879.
[11]	Hoyos LR, Visser JA, McLuskey A，et al.Loss of anti-Müllerian hormone (AMH) immunoactivity due to a homozygous AMH gene variant rs10417628 in a woman with classical polycystic ovary syndrome (PCOS) [J]．Hum Reprod，2020，35(10)：2294-2302.
[12]	Shi Y, Li L, Zhou J，et al.Efficacy of electroacupuncture inregulating the imbalance of AMH and FSH to improve follicledevelopment and hyperandrogenism in PCOS rats[J]．Biomed Pharmacother，2019，(113)：108687.
[13]	寇丽辉，侯丽辉，孟小钰，等.300例糖尿病家族史多囊卵巢综合征患者的临床特征分析[J]．实用妇产科杂志，2018，34(11)：864-867.
[14]	Stracquadanio M, Ciotta L, Palumbo MA. Relationship between serum anti-Mullerian hormone and intrafollicular AMH levels in PCOS women[J]．Gynecol Endocrinol，2018，34(3)：223-228.
[15]	Detti L, Christiansen ME, Francillon L，et al.Serum anti-Müllerian hormone (AMH) in mothers with polycystic ovary syndrome (PCOS) and their term fetuses[J]．Syst Biol Reprod Med，2019，65(2)：147-154.
[16]	Zhang F, Liu XL, Rong N，et al.Clinical value of serum anti-mullerian hormone and inhibin B in prediction of ovarian response in patients with polycystic ovary syndrome[J]．J Huazhong Univ Sci Technolog Med Sci，2017，37(1)：70-73.
[17]	Lv PP, Jin M, Rao JP，et al.Role of anti-Müllerian hormone and testosterone in follicular growth：a cross-sectional study[J]．BMC Endocr Disord，2020，20(1)：101.
[18]	Evliyaoglu O, Imöhl M, Weiskirchen R，et al.Age-specific reference values improve the diagnostic performance of AMH in polycystic ovary syndrome[J]．Clin Chem Lab Med，2020，58(8)：1291-1301.
[19]	Sjaarda LA, Mumford SL, Kuhr DL，et al.Association of testosterone and antimüllerian hormone with time to pregnancy and pregnancy loss in fecund women attempting pregnancy[J]．Fertil Steril，2018，109(3)：540-548.
[20]	Pellatt L, Hanna L, Brincat M，et al.Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries[J]．J Clin Endocrinol Metab，2007，92(1)：240-245.
[21]	Dai X, Wang Y, Yang H，et al. AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles[J]．Sci Rep，2020，10(1)：19750.
[22]	唐婕，吴韶清，许遵鹏，等．血清抗苗勒氏管激素水平在多囊卵巢综合征患者中的诊断价值[J]．热带医学杂志，2019，19(11)：1386-1388.
[23]	Eilertsen TB, Vanky E, Carlsen SM.Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome：can morphologic description be replaced? [J]．Hum Reprod，2012，27(8)：2494-2502.
[24]	Rosenfield RL, Wroblewski K, Padmanabhan V，et al.Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries[J]．Fertil Steril，2012，98(1)：242-249.
[25]	Yue CY, Lu LK, Li M，et al.Threshold value of anti-Mullerian hormone for the diagnosis of polycystic ovary syndrome in Chinese women[J]．PLoS One，2018，13(8)：e0203129.
[26]	Shi X, Peng D, Liu Y，et al.Advantages of serum anti-müllerian hormone as a marker for polycystic ovarian syndrome[J]．Lab Med，2019，50(3)：236-242.
[27]	Vagios S, James KE, Sacha CR, et al. A patient-specific model combining antimüllerian hormone and body mass index as a predictor of polycystic ovary syndrome and other oligo-anovulation disorders[J]．Fertil Steril，2021，115(1)：229-237.
[28]	Pankhurst MW, Shorakae S, Rodgers RJ，et al.Efficacy of predictive models for polycystic ovary syndrome using serum levels of two antimüllerian hormone isoforms (proAMH and AMH_N，C)[J]．Fertil Steril，2017，108(5)：851-857.
[29]	Asanidze E, Kristesashvili J, Pkhaladze L，et al.The value of anti-Mullerian hormone in the management of polycystic ovary syndrome inadolescents[J]．Gynecol Endocrinol，2019，35(11)：974-977.

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