To investigate the relationship between the severity and the level of hypersensitive C-reactive protein (hs-CRP) in schizophrenic.

From April 2019 to April 2020, a total of 214 outpatients and inpatients with schizophrenia were selected from the Department of Psychiatry in Yangjiang Public Health Hospital, with 107 new or recurrent patients as the observation group and 107 patients with stable condition as the control group. Patients in both groups were given antipsychotic medications, and the Positive and Negative Symptom Scale (PANSS) as well as serum hs-CRP levels were measured before and 1 month after treatment. The correlation between hS-CRP level and total PANSS score in the observation group before and after treatment was analyzed by Pearson correlation.

The total PANSS score and hs-CRP level in the observation group were (66.97±9.53) points and 8.30(2.10, 20.10)mg/L before treatment, and (46.48±7.16) points and 1.90(0.60, 5.20)mg/L after treatment, respectively. The total PANSS score and hs-CRP level in the control group were (30.38±5.34) points and 0.90(0.40, 2.05)mg/L before treatment, and (30.68±2.63) points and 1.00(0.40, 2.73)mg/L after treatment, respectively. PANSS total score and hs-CRP level of the two groups were compared before treatment (t=33.96, Z=-7.98) and after treatment (t=21.02, Z=-2.49), and the differences were statistically significant(all P<0.05). The total PANSS score and hs-CRP level in the observation group decreased significantly with the remission of the disease (t=20.99, Z=-7.18) (all P<0.01). Correlation analysis results showed that before treatment (r₁=0.73) and after treatment (r₂=0.41), the serum hs-CRP level in observation group were positively correlated with the total score of PANSS (all P<0.01).

The severity of schizophrenia is closely related to the level of serum hs-CRP. Detection of hs-CRP has high application value in dynamically observing the condition of patients with schizophrenia.