The diagnostic value of the triglyceride-glucose index in predicting the risk of non-alcoholic fatty liver disease in physical examination population

doi:10.3877/cma.j.issn.2095-655X.2022.03.002

Abstract

Abstract:

Objective

To explore the predictive value of triglyceride-glucose (TyG) index on the risk of non-alcoholic fatty liver disease (NAFLD) in physical examination population.

Methods

From December 2018 to December 2019, a total of 8 860 employees from Xinjiang Oilfield Company and Western Drilling Company who underwent physical examinations in the Karamay Integrated Chinese and Western Hospital (Municipal People′s Hospital) were chosen as the research subjects. The subjects′ general clinical data, blood biochemical indexes, and ultrasonic examination results were collected, and the TyG index was calculated. The risk factors for NAFLD were studied using multivariate logistic regression. The receiver operating characteristic (ROC) curve was used to assess the predictive value of the TyG index for NAFLD.

Results

NAFLD affected 3 261 patients. The TyG index, age, systolic blood pressure, abdominal girth, and alanine aminotransferase were found to be independent risk factors for NAFLD, with ORs of 3.294(2.933-3.699), 1.013(1.006-1.020), 1.007(1.001-1.012), 1.092(1.085-1.100), and 1.029(1.026-1.033)(all P<0.05). The area under the curve (AUC) of TyG index was 0.818 according to the ROC curve analysis, and the cut-off value of TyG index in diagnosing NAFLD was 4.310.

Conclusion

The TyG index can better predict NAFLD risk and be used as an effective indicator for screening NAFLD high-risk populations.

Key words: Physical examination, Triglyceride-glucose index, Non-alcoholic fatty liver disease, Forecasting

Meiyu Zhang, Shengli Wu, Weiting Xiang, Kehong Sun, Nong Li. The diagnostic value of the triglyceride-glucose index in predicting the risk of non-alcoholic fatty liver disease in physical examination population[J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 152-157.

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References 24

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项目	NAFLD组(n＝3 261)	无NAFLD组(n＝5 599)	统计量	P值
年龄(岁，±s)	41.41±8.86	37.71±9.15	t＝－18.58	<0.01
性别(男/女，例)	2 721/540	2 669/2 930	χ²＝1 108.02	<0.01
BMI(kg/m²，±s)	27.66±4.20	23.96±4.35	t＝－4.83	<0.01
SBP(mmHg，±s)	128.50±16.58	117.29±14.74	t＝－32.66	<0.01
DBP(mmHg，±s)	81.87±12.21	72.70±11.20	t＝－35.60	<0.01
腰围(cm，±s)	95.16±12.60	81.87±10.24	t＝－53.55	<0.01
BMI超标/正常(例)	2 539/722	1 625/3 974	χ²＝1 956.44	<0.01
腰围超标/正常(例)	2 448/813	1 645/3 954	χ²＝1 544.46	<0.01
FBG(mmol/L，±s)	6.25±2.08	5.38±1.05	t＝－25.98	<0.01
TG[mmol/L，M(P₂₅，P₇₅)]	2.14(1.51，3.05)	1.12(0.80，1.63)	Z＝－45.68	<0.01
TC(mmol/L，±s)	5.01±1.04	4.56±0.95	t＝－20.31	<0.01
ALT[U/L，M(P₂₅，P₇₅)]	32.00(23.00，48.00)	16.00(12.00，24.00)	Z＝－48.17	<0.01
TyG指数(±s)	4.77±0.63	4.03 ±0.58	t＝－56.72	<0.01

项目	NAFLD组(n＝3 261)	无NAFLD组(n＝5 599)	统计量	P值
年龄(岁，±s)	41.41±8.86	37.71±9.15	t＝－18.58	<0.01
性别(男/女，例)	2 721/540	2 669/2 930	χ²＝1 108.02	<0.01
BMI(kg/m²，±s)	27.66±4.20	23.96±4.35	t＝－4.83	<0.01
SBP(mmHg，±s)	128.50±16.58	117.29±14.74	t＝－32.66	<0.01
DBP(mmHg，±s)	81.87±12.21	72.70±11.20	t＝－35.60	<0.01
腰围(cm，±s)	95.16±12.60	81.87±10.24	t＝－53.55	<0.01
BMI超标/正常(例)	2 539/722	1 625/3 974	χ²＝1 956.44	<0.01
腰围超标/正常(例)	2 448/813	1 645/3 954	χ²＝1 544.46	<0.01
FBG(mmol/L，±s)	6.25±2.08	5.38±1.05	t＝－25.98	<0.01
TG[mmol/L，M(P₂₅，P₇₅)]	2.14(1.51，3.05)	1.12(0.80，1.63)	Z＝－45.68	<0.01
TC(mmol/L，±s)	5.01±1.04	4.56±0.95	t＝－20.31	<0.01
ALT[U/L，M(P₂₅，P₇₅)]	32.00(23.00，48.00)	16.00(12.00，24.00)	Z＝－48.17	<0.01
TyG指数(±s)	4.77±0.63	4.03 ±0.58	t＝－56.72	<0.01

项目	B	SE	Wald χ²值	P值	OR值	95%CI
项目	B	SE	Wald χ²值	P值	OR值	下限	上限
年龄(岁)	0.013	0.004	12.893	0.000	1.013	1.006	1.020
性别	－0.148	0.077	3.683	0.055	0.862	0.741	1.003
腰围(cm)	0.088	0.004	579.794	0.000	1.092	1.085	1.100
BMI(kg/m²)	0.165	0.001	0.047	0.829	1.000	0.998	1.001
SBP(mmHg)	0.007	0.003	5.660	0.017	1.007	1.001	1.012
DBP(mmHg)	0.005	0.004	1.600	0.206	1.005	0.997	1.013
TC(mmol/L)	－0.029	0.031	0.899	0.343	0.971	0.914	1.032
ALT(U/L)	0.029	0.002	248.699	0.000	1.029	1.026	1.033
TyG指数	1.192	0.059	405.829	0.000	3.294	2.933	3.699
常数项	－15.97	0.409	1 521.313	0.000	0.000

项目	B	SE	Wald χ²值	P值	OR值	95%CI
项目	B	SE	Wald χ²值	P值	OR值	下限	上限
年龄(岁)	0.013	0.004	12.893	0.000	1.013	1.006	1.020
性别	－0.148	0.077	3.683	0.055	0.862	0.741	1.003
腰围(cm)	0.088	0.004	579.794	0.000	1.092	1.085	1.100
BMI(kg/m²)	0.165	0.001	0.047	0.829	1.000	0.998	1.001
SBP(mmHg)	0.007	0.003	5.660	0.017	1.007	1.001	1.012
DBP(mmHg)	0.005	0.004	1.600	0.206	1.005	0.997	1.013
TC(mmol/L)	－0.029	0.031	0.899	0.343	0.971	0.914	1.032
ALT(U/L)	0.029	0.002	248.699	0.000	1.029	1.026	1.033
TyG指数	1.192	0.059	405.829	0.000	3.294	2.933	3.699
常数项	－15.97	0.409	1 521.313	0.000	0.000

项目	模型1 OR值(95%CI)	P值	模型2 OR值(95%CI)	P值
总体	7.548(6.864~8.30)	<0.001	3.294(2.933~3.699)	<0.01
男性	4.767(4.272~5.320)	<0.001	2.665(2.346~3.028)	<0.01
女性	11.662(9.376~14.505)	<0.001	6.652(5.067~8.732)	<0.01
BMI≥25 kg/m²	4.263(3.757~4.837)	<0.001	2.839(2.451~3.289)	<0.01
BMI<25 kg/m²	7.223(6.172~8.453)	<0.001	3.826 (3.167~4.622)	<0.01
腰围超标	5.093(4.481~5.789)	<0.001	3.143(2.708~3.648)	<0.01
腰围正常	7.407(6.362~8.624)	<0.001	3.645(3.041~4.369)	<0.01

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