Research progress of mitochondrial dysfunction and premature ovarian failure

doi:10.3877/cma.j.issn.2095-655X.2023.04.013

Abstract

Abstract:

Premature ovarian failure (POF) is a common reproductive endocrine disorder that mostly appears as premature amenorrhea due to ovarian failure and has a significant negative impact on the health of women. As significant organelles, mitochondria play multiple roles in a variety of biological processes, including cell development, information transmission, and apoptosis, whose malfunction is thought to result in the occurrence of POF. The authors mainly investigate the consequences of mitochondrial abnormalities on POF from 4 viewpoints, namely, imbalanced mitochondrial energy metabolism, imbalanced mitochondrial calcium metabolism, mitochondrial DNA mutation, and mitochondrial dynamics changes. By outlining the disease′s pertinent mechanism, the treatment plan for POF is evaluated together with its future prospects.

Key words: Premature ovarian failure, Mitochondrial DNA, Mitochondrial energy metabolism, Calcium metabolism, Mitochondrial dynamics

Qianxue Yu, Xuemei Liao, Longlong Sun, Mengying Fan, Mingchao Jiang, Hui Meng, Ruiji Li. Research progress of mitochondrial dysfunction and premature ovarian failure[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(04): 283-288.

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