Research progress on the mechanism of intercellular communication and metabolic microenvironment in arterial calcification

doi:10.3877/cma.j.issn.2095-655X.2024.03.010

Abstract

Abstract:

Arterial calcification is a pathological process characterized by the translocation of minerals such as calcium and phosphorus onto the arterial wall, which is often secondary to a variety of diseases. Intercellular communication and interaction play an important role in the development of arterial calcification. Although the phenotypic transition of vassular smooth muscle cells is considered to be a main feature of arterial calcification, the mechanism leading to the loss of contractile phenotype and driving the phenotypic transformation of calcification is not fully understood. The purpose of this review is to summarize the latest progress in the study of phenotypic transformation of vascular smooth muscle cells, their communication with different cells, and the metabolic microenvironment in vivo in the development of arterial calcification, so as to further understand the mechanism of arterial calcification.

Key words: Arteries, Vascular calcification, Myocytes, smooth muscle, Osteoclasts, Endothelial cells

Pan Feng, Qiuhua Liang. Research progress on the mechanism of intercellular communication and metabolic microenvironment in arterial calcification[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(03): 193-198.

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References 56

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囊泡来源	干预因素	细胞外囊泡分泌的物质	对动脉钙化的影响	相关分子及机制	参考文献
平滑肌细胞	高糖	IL-1β	促进钙化	自噬	[54]
巨噬细胞	高磷	let-7b-5p	促进钙化	Smad3/Runx2	[38]
	高糖	miR-32	促进钙化	自噬	[37]
	脂多糖	IL-6、IL-1β、TNF-α、CAD、PAI-1、Saa3	促进钙化	炎症、氧化应激	[39]
内皮细胞	高磷	miR-670-3p	促进钙化	IGF-1	[24]
	高磷	STAT1	促进钙化	Wnt/β-catenin	[26]
	AGEs	miR-126-5p	抑制钙化	BMPR1B- Smad1/5/9	[23]
外膜成纤维细胞	高磷	miR-21-5p	促进钙化	Crim1	[44]
骨髓间充质干细胞	-	miR-381-3p	抑制钙化	NFATc5	[47]
	-	miR-15a/15b/16	抑制钙化	NFATc3/OCN	[48]
其他	鼠李糖乳杆菌	-	促进钙化	PI3K/AKT	[55]
	CKD大鼠血清	miR-16-5p、miR-17-5p、miR-20a-5p、miR-106b-5p	促进钙化	VEGFA	[10]
	低温	miR-320a-3p	抑制钙化	AMPK/mTOR	[56]

囊泡来源	干预因素	细胞外囊泡分泌的物质	对动脉钙化的影响	相关分子及机制	参考文献
平滑肌细胞	高糖	IL-1β	促进钙化	自噬	[54]
巨噬细胞	高磷	let-7b-5p	促进钙化	Smad3/Runx2	[38]
	高糖	miR-32	促进钙化	自噬	[37]
	脂多糖	IL-6、IL-1β、TNF-α、CAD、PAI-1、Saa3	促进钙化	炎症、氧化应激	[39]
内皮细胞	高磷	miR-670-3p	促进钙化	IGF-1	[24]
	高磷	STAT1	促进钙化	Wnt/β-catenin	[26]
	AGEs	miR-126-5p	抑制钙化	BMPR1B- Smad1/5/9	[23]
外膜成纤维细胞	高磷	miR-21-5p	促进钙化	Crim1	[44]
骨髓间充质干细胞	-	miR-381-3p	抑制钙化	NFATc5	[47]
	-	miR-15a/15b/16	抑制钙化	NFATc3/OCN	[48]
其他	鼠李糖乳杆菌	-	促进钙化	PI3K/AKT	[55]
	CKD大鼠血清	miR-16-5p、miR-17-5p、miR-20a-5p、miR-106b-5p	促进钙化	VEGFA	[10]
	低温	miR-320a-3p	抑制钙化	AMPK/mTOR	[56]

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