Research progress on application of multi-omics technologies in acute lung injury

doi:10.3877/cma.j.issn.2095-655X.2025.03.003

Abstract

Abstract:

Acute lung injury (ALI) is a critical syndrome characterized by respiratory failure and induced by diverse etiologies, with a complex pathogenesis and high mortality rate. Although conventional diagnostic and therapeutic approaches are widely used in clinical practice, their efficacy remains constrained by various factors. In recent years, multi-omics technologies based on high-throughput sequencing have provided significant insights into the molecular mechanisms of ALI, as well as the identification of novel diagnostic biomarkers and potential therapeutic targets. This article provides a comprehensive review of the latest advancements in multi-omics technologies in ALI research and summarizes their advantages and prospects in elucidating disease mechanisms, facilitating early clinical diagnosis, and promoting targeted therapy. This review aims to provide a theoretical foundation for future basic and translational research on ALI.

Key words: Acute lung injury, Genomics, Transcriptomics, Proteomics, Metabolomics

Ke Yang, Zihe Cheng, Shengyu Wang. Research progress on application of multi-omics technologies in acute lung injury[J]. Chinese Journal of Diagnostics(Electronic Edition), 2025, 13(03): 159-164.

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