Abstract:
Objective To explore clinical significance of the provocative GH testing in clinical diagnosis of short children.
Methods Retrospective analysis of two hundred and forty-three cases of short children from February 2013 to April 2014, who were tested with levodopa and insulin test.Determing growth basic values and growth values after 30, 60, 90, 120min of giving medicine.
Results Sixty-eight cases(27.98%) with complete lack of growth hormone, ninty-eight patients (40.33%) with partial growth hormone deficiency, sixty-six cases (27.16%) with idiopathic short stature, seven cases (2.88%) with Turner syndrome, four cases with other causes (1.65%). Growth hormone deficiencies was the first cause.Comparing with the partial growth hormone deficiency, there was a significant difference(χ2=6.533, P<0.05). The peak(6.39±3.81)μg/L of growth hormone in L-dopa provocation tests was higher than the peak of growth hormone (5.02±3.57)μg/L in insulin provocation tests, but there was no statistically significant difference (t=1.640, P>0.05); The peak of growth hormone in L-dopa provocation tests appeared in 60min, (one hundred and nineteen cases, 48.97%), the peak of growth hormone in insulin stimulates test in 30min, 60min respectively (one hundred and thirteen cases, 46.50%; one hundred and twenty-one cases, 49.80%).
Conclusion Provocation GH testing of levodopa and insulin can be used as diagnostic test of short children with growth hormone deficiency.
Key words:
Short stature,
Growth hormone,
Levodopa,
Insulin
Hailing Sun, Bo Ban, Hui Pan, Huijuan Zhu, Mei Zhang, Ping Li. Clinical significance of the provocative GH testing in clinical diagnosis of short children[J]. Chinese Journal of Diagnostics(Electronic Edition), 2014, 02(02): 105-108.