The effects of propranolol on the left ventricular function by 64-slice multi-slice computed tomography

doi:10.3877/cma.j.issn.2095-655X.2014.04.001

Abstract

Abstract:

Objective

To investigate the effects of propranolol on the left ventricular (LV) function by CT coronary angiography.

Methods

One hundred and seventy-eight subjects without coronary artery stenosis were examined by 64SCT coronary angiography (64SCTA). Eight-nine subjects did not take propranolol while another eight-nine age-and gender-matched subjects whose heart rates above 70 beats were chosen to take propranolol.The heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) before and after the administration of propranolol and the dosage of propranolol were recorded.The left ventricular function was calculated by parameters of end-diastolic volume(EDV), end systolic volume(ESV) and ejection fraction(EF). The paired-t test was used to compare the left ventricular function between the two groups (no taking and taking propranolol).

Results

There were no significant differences in the SBP and DBP between the groups without and with propranolol medication [(124±14)mmHg and (81±9)mmHg; (121±13)mmHg and (79±10)mmHg, respectively)]. The EDV showed no significant differences between the two groups, but the ESV and EF showed significant differences between the two groups[(44.7±12.3)mL and (47.3±13.4)mL; (65.1±8.4)% and (62.0±7.8)%, respectively)].

Conclusions

Taking propranolol increases ESV and decreases EF, while the SBP, DBP and EDV don′t change.

Key words: Ventricular function, left, Tomography, spiral computed, Adrenergic beta-antagonists

Chunhong Zhang, Jun Liu, Lihua Liang, Shuping Peng. The effects of propranolol on the left ventricular function by 64-slice multi-slice computed tomography[J]. Chinese Journal of Diagnostics(Electronic Edition), 2014, 02(04): 245-248.

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Figures/Tables 2

References 19

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组别	例数	年龄(岁)	体质量(kg)	身高(cm)
未用药组	89	61.0± 9.0	65.4±11.5	160.2±7.0
用药组	89	60.0±10.0	66.1±11.0	161.6±7.5
t值	?	1.52	0.42	1.28
P值	?	>0.05	>0.05	>0.05

组别	例数	年龄(岁)	体质量(kg)	身高(cm)
未用药组	89	61.0± 9.0	65.4±11.5	160.2±7.0
用药组	89	60.0±10.0	66.1±11.0	161.6±7.5
t值	?	1.52	0.42	1.28
P值	?	>0.05	>0.05	>0.05

组别	例数	EDV(mL)	ESV(mL)	EF(%)	SBP(mmHg)	DBP(mmHg)
未用药组	89	127.5±16.4	44.7±12.3	65.1±8.4	124±14	81±9
用药组	89	129.8±15.1	47.3±13.4	62.0±7.8	121±13	79±10
t值	?	－1.22	－2.47	2.93	1.04	1.44
P值	?	>0.05	<0.05	<0.05	>0.05	>0.05

组别	例数	EDV(mL)	ESV(mL)	EF(%)	SBP(mmHg)	DBP(mmHg)
未用药组	89	127.5±16.4	44.7±12.3	65.1±8.4	124±14	81±9
用药组	89	129.8±15.1	47.3±13.4	62.0±7.8	121±13	79±10
t值	?	－1.22	－2.47	2.93	1.04	1.44
P值	?	>0.05	<0.05	<0.05	>0.05	>0.05

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