To analyze the effect of intelligence structure changes on comprehensive rehabilitation efficiency in children with infantile spasms(IS). This study may be benefit for guiding the clinical therapy and provide the theoretical basis for IS children prognosis.

Twenty-seven children with IS diagnosed in hospital from February 2009 to February 2013 were divided into the rehabilitation group(ninteen cases) and the control group(eight cases). All cases were treated with the anti-epilepsy drugs(AEDs) to control spasms.The rehabilitation group was combined with rehabilitation therapies.Three months after treatmeat, the neuropsychological development scales were used to test the score and distance of gross motor, exiguous, language, adaptive area, social intercourse and the development quotient(DQ). The difference of DQ points was compared with t-test.

The DQ points of the two groups of patients(the rehabilitation group: 59.40±7.85, the control group: 52.88±9.50)were significantly lower than those before(the rehabilitation group: 67.32±7.61, t=6.861, P<0.05; the control group: 67.86±8.39, t=8.875, P<0.05). The distances of gross motor(1.42±0.56, 0.75±0.38, t=3.091, P<0.05), fine motor(1.34±0.62, 0.81±0.53, t=2.095, P<0.05), language(1.32±0.48, 0.69±0.59, t=2.907, P<0.05) and DQ(-7.92±5.03, -14.99±4.78, t=3.379, P<0.05)of the rehabilitation group were significantly improved than those of the control group.Although there were some improvements in the distances of adaptive area(0.89±0.52, 0.5±0.38, t=1.946, P>0.05) and social intercourse(0.79±0.54, 0.56±0.42, t=1.066, P>0.05), there was no statistical significance.

The rehabilitation can improve the mental retardation of IS, especially in the aspects of gross motor, exiguous and language.