During the occurrence and development of wounds, the neurosecretory and immune systems act as a prominent leader navigator and possess an intrinsic crosstalk in the reciprocal information dissemination.The fundamental reason is that neuroendocrinology and immunology could mix with each other and permeate mutually.It is owing to their same biological languages or chemical information molecules (hormones, neurotransmitters, neuropeptides, cytokines and their corresponding receptors) shared by the neuroendocrine and immune systems.The immune system is modulated by the neuroendocrine system, and can modulate the biological functions of neuroendocrine system at the same time.The interactive linkage of these three systems precipitates the complicated space-time patterns for the courses of traumatic infections.Recently compelling evidences indicated that the network linkage pattern with neuroendocrine responses as initiating agents, immune cells as regulatory elements and immune regulatory molecules as effector targets arouse immune dysfunction after trauma, which supplies the beneficial enlightenment for the clinical diagnosis and therapy concerning the view of translation medicine.