Clinical thinking in the treatment of critically ill patients has its own characteristics on a basis of the general method.At first, based on a comprehensive assessment of the disease, the positive and effective interventions are taken for the major problems currently.The disease′s progression is blocked as fast as we can, to save time for the treatment of primary disease and create the conditions for the body recovery.The life-threatening problems are treated with the highest speed and the most effective measures to maintain the stable vital signs of patients.The prominent problems are resolved preferentially.To pursue "precise" , the patients′ response must be observed timely in the course of treatment.Because the main issues can change at different stages, the inflection point of the disease should be grasped in time during the treatment.The evolution of disease is observed and the diagnosis can be amended dynamically.The "Guide" and "expert consensus" are carried rationally and the emphasis of the individual differences should be based on standardization.The concept of "precision medicine" is the embodiment of individualized treatment.Meanwhile the uncertainty of clinical work must be treated in a right way.