Research progress of peripheral circulating tumor cells detection technology

doi:10.3877/cma.j.issn.2095-655X.2017.01.017

Abstract

Abstract:

Cancer metastasis is the main cause of cancer-related death, and dissemination of tumor cells through the blood circulation is an important intermediate step that also exemplifies the switch from localized to systemic disease.Early detection and characterization of circulating tumor cells (CTCs) is therefore important as a general strategy to monitor and prevent the development of overt metastatic disease.Furthermore, sequential analysis of CTCs can provide clinically relevant information on the effectiveness and progression of systemic therapies.Although many advances have been made regarding the detection of CTCs, several challenges still exist that limit the current use of this important diagnostic approach.In this review, we will mainly discuss the technical advances, as well as the challenges of CTC detection and characterization.

Key words: Neoplasms, Neoplastic cells, circulating, Early detection of cancer

Tongmei Zhang, Baolan Li. Research progress of peripheral circulating tumor cells detection technology[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(01): 62-66.

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References 46

[1]	Zhang L,Riethdorf S,Wu G, et al.Meta-analysis of the prognostic value of circulating tumor cells in breast cancer [J]. Clin Cancer Res, 2012, 18(20): 5701-5710.
[2]	Bidard FC,Peeters DJ,Fehm T, et al.Clinical validity of circulating tumour cells in patients with metastatic breast cancer：A pooled analysis of individual patient data [J]. Lancet Oncology, 2014, 15(4): 406-414.
[3]	de Bono JS,Scher HI,Montgomery RB, et al.Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer [J]. Clin Cancer Res, 2008, 14(19): 6302-6309.
[4]	Cohen SJ,Punt CJ,Iannotti N, et al.Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer [J]. J Clin Oncol, 2008, 26(19): 3213-3221.
[5]	Krebs MG,Sloane R,Priest L, et al.Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer [J]. J Clin Oncol, 2011, 29(12): 1556-1563.
[6]	Hou JM,Krebs MG,Lancashire L, et al.Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer [J]. J Clin Oncol, 2012, 30(5): 525-532.
[7]	Budd GT,Cristofanilli M,Ellis MJ, et al.Circulating tumor cells versus imaging-predicting overall survival in metastatic breast cancer [J]. Clin Cancer Res, 2006, 12(21): 6403-6409.
[8]	Cayrefourcq L,Mazard T,Joosse S, et al. Establishment and characterization of a cell line from human circulating colon cancer cells [J]. Cancer Res, 2015, 75(5): 892-901.
[9]	Yu M,Bardia A,Aceto N, et al.Cancer therapy.Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility [J]. Science, 2014, 345(6193): 216-220.
[10]	TR A. A case of cancer in which cells similar to those in the tumours were seen in the blood after death [J]. Aust Med J, 1869, 14(3): 146-149.
[11]	Nowell PC.The clonal evolution of tumor cell populations [J]. Science, 1976, 194(4260): 23-28.
[12]	Farace F,Massard C,Vimond N, et al.A direct comparison of cellsearch and iset for circulating tumour-cell detection in patients with metastatic carcinomas [J]. Br J Cancer, 2011, 105(6): 847-853.
[13]	Parkinson DR,Dracopoli N,Petty BG, et al.Considerations in the development of circulating tumor cell technology for clinical use [J]. J Transl Med, 2012(10): 138.
[14]	Alix-Panabières C,Pantel K. Technologies for detection of circulating tumor cells：Facts and vision [J]. Lab chip, 2014, 14(1): 57-62.
[15]	Riethdorf S,Fritsche H,Müller V, et al.Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer：A validation study of the cellsearch system [J]. Clin Cancer Res, 2007, 13(3): 920-928.
[16]	Gasch C,Bauernhofer T,Pichler M, et al.Heterogeneity of epidermal growth factor receptor status and mutations of kras/pik3ca in circulating tumor cells of patients with colorectal cancer [J]. Clin Chem, 2013, 59(1): 252-260.
[17]	Armstrong AJ,Marengo MS,Oltean S, et al.Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers [J]. Mol Cancer Res, 2011, 9(8): 997-1007.
[18]	Tewes M,Aktas B,Welt A, et al.Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer：An option for monitoring response to breast cancer related therapies [J]. Breast Cancer Res Treat, 2009, 115(3): 581-590.
[19]	Thege FI,Lannin TB,Saha TN, et al.Microfluidic immunocapture of circulating pancreatic cells using parallel epcam and muc1 capture：Characterization, optimization and downstream analysis [J]. Lab chip, 2014, 14(10): 1775-1784.
[20]	Ozkumur E,Shah AM,Ciciliano JC, et al.Inertial focusing for tumor antigen-dependent and-independent sorting of rare circulating tumor cells [J]. Sci Transl Med, 2013, 5(179): 179ra147.
[21]	Harb W,Fan A,Tran T, et al.Mutational analysis of circulating tumor cells using a novel microfluidic collection device and qpcr assay [J]. Transl Oncol, 2013, 6(5): 528-538.
[22]	Saucedo-Zeni N,Mewes S,Niestroj R, et al.A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire [J]. Int J Oncol, 2012, 41(4): 1241-1250.
[23]	Lin HK,Zheng S,Williams AJ, et al.Portable filter-based microdevice for detection and characterization of circulating tumor cells [J]. Clin Cancer Res, 2010, 16(20): 5011-5018.
[24]	Hou HW,Warkiani ME,Khoo BL, et al.Isolation and retrieval of circulating tumor cells using centrifugal forces [J]. Sci Rep, 2013(3): 1259.
[25]	Sollier E,Go DE,Che J, et al.Size-selective collection of circulating tumor cells using vortex technology [J]. Lab chip, 2014, 14(1): 63-77.
[26]	Hosokawa M,Hayata T,Fukuda Y, et al.Size-selective microcavity array for rapid and efficient detection of circulating tumor cells [J]. Anal Chem, 2010, 82(15): 6629-6635.
[27]	Lee A,Park J,Lim M, et al.All-in-one centrifugal microfluidic device for size-selective circulating tumor cell isolation with high purity [J]. Anal Chem, 2014, 86(22): 11349-11356.
[28]	Wu S,Liu Z,Liu S, et al.Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions [J]. Clin Chem Lab Med, 2014, 52(2): 243-251.
[29]	Riahi R,Gogoi P,Sepehri S, et al.A novel microchannel-based device to capture and analyze circulating tumor cells (ctcs) of breast cancer [J]. Int J Oncol, 2014, 44(6): 1870-1878.
[30]	Mani SA,Guo W,Liao MJ, et al.The epithelial-mesenchymal transition generates cells with properties of stem cells [J]. Cell, 2008, 133(4): 704-715.
[31]	Ota I,Li XY,Hu Y, et al.Induction of a mt1-mmp and mt2-mmp-dependent basement membrane transmigration program in cancer cells by snail1 [J]. Proc Natl Acad Sci U S A, 2009, 106(48): 20318-20323.
[32]	Bonnomet A,Brysse A,Tachsidis A, et al.Epithelial-to-mesenchymal transitions and circulating tumor cells [J]. J Mammary Gland Biol Neoplasia, 2010, 15(2): 261-273.
[33]	Iinuma H,Watanabe T,Mimori K, et al.Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with dukes' stage b and C colorectal cancer [J]. J Clin Oncol, 2011, 29(12): 1547-1555.
[34]	Lu J,Fan T,Zhao Q, et al.Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients [J]. Int J Cancer, 2010, 126(3): 669-683.
[35]	Alshareef M,Metrakos N,Juarez Perez E, et al.Separation of tumor cells with dielectrophoresis-based microfluidic chip [J]. Biomicrofluidics, 2013, 7(1): 11803.
[36]	Nagrath S,Sequist LV,Maheswaran S, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology [J]. Nature, 2007, 450(7173): 1235-1239.
[37]	Maheswaran S,Sequist LV,Nagrath S, et al.Detection of mutations in egfr in circulating lung-cancer cells [J]. N Engl J Med, 2008, 359(4): 366-377.
[38]	Babayan A,Hannemann J,Spötter J, et al.Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients [J]. PloS one, 2013, 8(9): e75038.
[39]	Pantel K,Denève E,Nocca D, et al.Circulating epithelial cells in patients with benign colon diseases [J]. Clin Chem, 2012, 58(5): 936-940.
[40]	Yu M,Bardia A,Wittner BS, et al.Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition [J]. Science, 2013, 339(6119): 580-584.
[41]	Yokobori T,Iinuma H,Shimamura T, et al. Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis [J]. Cancer Res, 2013, 73(7): 2059-2069.
[42]	Pantel K,Alix-Panabières C. Circulating tumour cells in cancer patients：Challenges and perspectives [J]. Trends Mol Med, 2010, 16(9): 398-406.
[43]	Alix-Panabières C,Pantel K. Challenges in circulating tumour cell research [J]. Nat Rev Cancer, 2014, 14(9): 623-631.
[44]	Hyun KA,Jung HI. Advances and critical concerns with the microfluidic enrichments of circulating tumor cells [J]. Lab Chip, 2014, 14(1): 45-56.
[45]	Sequist LV,Nagrath S,Toner M, et al.The ctc-chip：An exciting new tool to detect circulating tumor cells in lung cancer patients [J]. J Thorac Oncol, 2009, 4(3): 281-283.
[46]	Kamande JW,Hupert ML,Witek MA, et al.Modular microsystem for the isolation, enumeration, and phenotyping of circulating tumor cells in patients with pancreatic cancer [J]. Anal Chem, 2013, 85(19): 9092-9100.

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