Diagnostic features of insulin autoimmune syndrome caused by Methimazole

doi:10.3877/cma.j.issn.2095-655X.2018.03.012

Abstract

Abstract:

Objective

To explore the diagnostic features of insulin autoimmune syndrome (IAS).

Methods

A retrospective analysis was performed in one patient diagnosed as IAS in Department of Endocrinology of the Third Affiliated Hospital of Sun Yat-sen University. Then the relevant literatures were reviewed.

Results

A 19-year female patient with Graves disease suffered from serious hypoglycemia after she had taken Methimazole for more than ten days. The insulin releasing index was 4.13 when her blood glucose was 2.73 mmol/L. The ratios of fasting insulin/fasting C-peptide were within 8.20-15.12. The insulin auto-antibody (IAA) was positive. The patient′s pancreas was normal in abdomen enhanced MR.

Conclusion

IAS should be considered when a patient with autoimmune disease suffers from hypoglycemia, especially while the patient is taking sulfhydryl-containing drugs.

Key words: Insulin autoimmune syndrome, Hypoglycemia, Graves disease, Methimazole

Panwei Mu, Ying Tan, Longyi Zeng. Diagnostic features of insulin autoimmune syndrome caused by Methimazole[J]. Chinese Journal of Diagnostics(Electronic Edition), 2018, 06(03): 198-201.

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