Application and challenge of polygenic risk score in prevention and prediction of schizophrenia

doi:10.3877/cma.j.issn.2095-655X.2021.03.002

Abstract

Abstract:

Schizophrenia is a complex disease with high heritability. Many susceptibility loci have been found in candidate genes and genome-wide association studies. Recently, polygenic risk score (PRS) has been playing an important role in the diagnosis, discrimination, and prediction of schizophrenia. Also, PRS could provide important assistance for the early prevention and treatment of potential schizophrenics in the future. This article discusses the application and challenges of PRS in the prevention and prediction of schizophrenia.

Key words: Schizophrenia, Polygenic risk score, Prevention, Prediction

Qiaojun Li, Xingping Lyu, Jiayuan Xu, Chuanjun Zhuo. Application and challenge of polygenic risk score in prevention and prediction of schizophrenia[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(03): 149-151.

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