Research progress of ferroptosis in the pathogenesis of Alzheimer′s disease

doi:10.3877/cma.j.issn.2095-655X.2022.03.013

Abstract

Abstract:

Alzheimer′s disease (AD) is a common neurodegenerative disease which is closely related to aging. AD is becoming more common with the aggravation of population aging, the incidence rate of it increases year by year. Ferroptosis is a type of cell death distinct from apoptosis, necrosis, and autophagy. Ferroptosis is distinguished by iron-dependent lipid peroxidation, glutathione depletion, and iron overload. Glutathione peroxidase 4 (GPX4) is a selenoprotein with anti-lipid peroxidation and is a key regulator in ferroptosis. Lipid peroxidation, iron metabolism disruption, and ferroptosis caused by selenium deficiency demonstrate close relationship with AD. This paper summarizes the key mechanisms and research progress of ferroptosis in AD, as well as the prospects of ferroptosis in the treatment of AD.

Key words: Ferroptosis, Alzheimer disease, Glutathione peroxidase 4

Qian Liu, Xin Li, Xin Liu, Jinxiang Yuan. Research progress of ferroptosis in the pathogenesis of Alzheimer′s disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 211-215.

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