To investigate the correlation between the rs4597342 polymorphism of the CD11b gene and Kawasaki disease(KD) and coronary artery lesions(CAL).

From January 1, 2019, to December 30, 2021, a total of 136 children with KD and 74 healthy children were selected from the Pediatrics Department of Zhuzhou Central Hospital. KD children were divided into KD with CAL group(KD-CAL group, n=25) and without CAL group (KD-NCAL group, n=111). The rs4597342 polymorphism of CD11b gene was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) combined with Sanger sequencing method. The genotype and allele frequency distribution of rs4597342 between KD and control groups, as well as between the KD-CAL and KD-NCAL groups were compared by using the χ² test.

The TT, TC, and CC genotype distribution frequencies at rs4597342 of the CD11b gene in the KD group were 5.89%, 47.78%, and 46.32%, respectively, and the T and C allele frequencies were 29.78%, 70.22%, respectively. The TT, TC, CC genotype distribution frequencies at rs4597342 of the CD11b gene in the healthy group were 1.35%, 50.00%, 48.65%, respectively, and the T and C allele frequencies were 26.35%, 73.65%, respectively. There were no significant differences in genotype and allele frequency distribution between the two groups (χ²=2.40, 0.55, all P>0.05). The TT, TC, and CC genotype distribution frequencies at rs4597342 of CD11b gene in KD-CAL group were 4.00%, 48.00% and 48.00%, respectively, and the frequencies of T and C alleles were 28.00%, 72.00%, respectively. TT, TC, and CC genotype distribution frequencies at rs4597342 of CD11b gene in KD-NCAL group were 6.31%, 47.75% and 45.94%, respectively, and T and C allele frequencies were 30.18%, 69.82%, respectively. There were no significant differences between the two groups (χ²=0.20, 0.09, all P>0.05).

The rs4597342 polymorphism of CD11b gene and KD or its complication CAL are not significantly correlated.