Progress of whole blood transfusion for severe trauma care

doi:10.3877/cma.j.issn.2095-655X.2024.03.001

Abstract

Abstract:

In recent years, the mortality caused by severe trauma has increased significantly. Bleeding and hemorrhagic shock are correctable causes of early preventable death in trauma cases. Blood transfusion is a critical intervention. Whole blood transfusion is the earliest blood transfusion method, but with the increasing demand for blood and the gradual recognition of the risks of disease transmission and poor therapeutic effects associated with whole blood transfusion, component blood transfusion has gradually become the main blood transfusion method. However, the whole blood transfusion in Iraq War and Afghanistan war has attracted much attention because of its effectiveness, making whole blood transfusion once again a hot spot in the treatment of severe trauma. In order to guide the treatment of severe trauma, this paper reviews the legal basis, indication and safety, guarantee and process of whole blood transfusion in the treatment of severe trauma, and the effect of whole blood transfusion in the treatment of war injury and civilian trauma.

Key words: Wounds and injuries, Blood transfusion, Whole blood, Blood component transfusion

Nian Chen, Lianyang Zhang. Progress of whole blood transfusion for severe trauma care[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(03): 145-148.

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References 31

[1]	Rhee P，Joseph B，Pandit V，et al.Increasing trauma deaths in the United States[J].Ann Surg，2014，260(1)：13-21.DOI：10.1097/SLA.0000000000000600.
[2]	Callcut RA，Kornblith LZ，Conroy AS，et al.The why and how our trauma patients die：a prospective Multicenter Western Trauma Association study[J].J Trauma Acute Care Surg，2019，86(5)：864-870.DOI：10.1097/TA.0000000000002205.
[3]	Kauvar DS，Lefering R，Wade CE.Impact of hemorrhage on trauma outcome：an overview of epidemiology，clinical presentations，and therapeutic considerations[J].J Trauma，2006，60(6 Suppl)：S3-S11.DOI：10.1097/01.ta.0000199961.02677.19.
[4]	Eastridge BJ，Holcomb JB，Shackelford S．Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury[J].Transfusion，2019，59(S2)：1423-1428.DOI：10.1111/trf.15161.
[5]	Sanddal TL，Esposito TJ，Whitney JR，et al.Analysis of preventable trauma deaths and opportunities for trauma care improvement in utah[J].J Trauma，2011，70(4)：970-977.DOI：10.1097/TA.0b013e3181fec9ba.
[6]	Stansbury LG，Hess JR.Blood transfusion in World War I：the roles of lawrence bruce robertson and oswald hope robertson in the " most important medical advance of the war" [J].Transfus Med Rev，2009，23(3)：232-236.DOI：10.1016/j.tmrv.2009.03.007.
[7]	中华人民共和国国家卫生健康委员会．WS/T623-2018 全血和成分血使用[S].北京：中国标准出版社，2019.
[8]	Yazer MH，Cap AP，Spinella PC，et al.How do I implement a whole blood program for massively bleeding patients？[J].Transfusion，2018，58(3)：622-628.DOI：10.1111/trf.14474.
[9]	Butler FK Jr，Holcomb JB，Schreiber MA，et al.Fluid resuscitation for hemorrhagic shock in tactical combat casualty care：TCCC Guidelines Change 14-01-2 June 2014[J].J Spec Oper Med，2014，14(3)：13-38.DOI：10.55460/DPOC-JWIY.
[10]	Shackelford SA，Gurney JM，Taylor AL，et al.Joint trauma system，defense committee on trauma，and armed services blood program consensus statement on whole blood[J].Transfusion, 2021，61(Suppl 1)：S333-S335.DOI：10.1111/trf.16454.
[11]	Repine TB，Perkins JG，Kauvar DS，et al.The use of fresh whole blood in massive transfusion[J].J Trauma，2006，60(6 Suppl)：S59-S69.DOI：10.1097/01.ta.0000219013.64168.b2.
[12]	Yazer MH，Jackson B，Sperry JL，et al.Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients[J].J Trauma Acute Care Surg，2016，81(1)：21-26.DOI：10.1097/TA.0000000000001100.
[13]	Williams J，Merutka N，Meyer D，et al.Safety profile and impact of low-titer group O whole blood for emergency use in trauma[J].J Trauma Acute Care Surg，2020，88(1)：87-93.DOI：10.1097/TA.0000000000002498.
[14]	王政军，张玉龙，周欠欠，等．全血在应急输血救治中的应用进展[J].中国输血杂志，2019，32(6)：598-602.DOI：10.13303/j.cjbt.issn.1004-549x.2019.06.026.
[15]	Spinella PC, Pidcoke HF, Strandenes G，et al.Whole blood for hemostatic resuscitation of major bleeding[J].Transfusion，2016，56( Suppl 2)：S190-S202.DOI：10.1111/trf.13491.
[16]	Slichter SJ，Fitzpatrick L，Osborne B，et al.Platelets stored in whole blood at 4℃：in vivo posttransfusion platelet recoveries and survivals and in vitro hemostatic function[J].Transfusion，2019，59(6)：2084-2092.DOI：10.1111/trf.15302.
[17]	Leeper CM，Yazer MH，Cladis FP，et al.Cold-stored whole blood platelet function is preserved in injured children with hemorrhagic shock[J].J Trauma Acute Care Surg，2019，87(1)：49-53.DOI：10.1097/TA.0000000000002340.
[18]	Strandenes G，Austlid I，Apelseth TO，et al.Coagulation function of stored whole blood is preserved for 14 days in austere conditions：a ROTEM feasibility study during a Norwegian antipiracy mission and comparison to equal ratio reconstituted blood[J].J Trauma Acute Care Surg，2015，78(6 Suppl 1)：S31-S38.DOI：10.1097/TA.0000000000000628.
[19]	王政军，宗玉鑫，谷立男，等．不同保存时间对4℃储存全血凝血功能的影响[J].军事医学，2019，43(3)：188-191.DOI：10.7644/j.issn.1674-9960.2019.03.007.
[20]	Repine TB，Perkins JG，Kauvar DS，et al.The use of fresh whole blood in massive transfusion[J].J Trauma，2006，60(6 Suppl)：S59-S69.DOI：10.1097/01.ta.0000219013.64168.b2.
[21]	Gurney JM, Spinella PC. Blood transfusion management in the severely bleeding military patient[J].Curr Opin Anaesthesiol，2018，31(2)：207-214.DOI：10.1097/ACO.0000000000000574.
[22]	Vanderspurt CK，Spinella PC，Cap AP，et al.The use of whole blood in US military operations in Iraq，Syria，and Afghanistan since the introduction of low-titer type O whole blood：feasibility，acceptability，challenges[J].Transfusion，2019，59(3)：965-970.DOI：10.1111/trf.15086.
[23]	Spinella PC，Perkins JG，Grathwohl KW，et al.Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries[J].J Trauma，2009，66(4 Suppl)：S69-S76.DOI：10.1097/TA.0b013e31819d85fb.
[24]	Gurney J，Staudt A，Cap A, et al. Improved survival in critically injured combat casualties treated with fresh whole blood by forward surgical teams in Afghanistan[J].Transfusion，2020，60(Suppl 3)：S180-S188.DOI：10.1111/trf.15767.
[25]	Gurney JM，Staudt AM，Del Junco DJ，et al.Whole blood at the tip of the spear：a retrospective cohort analysis of warm fresh whole blood resuscitation versus component therapy in severely injured combat casualties[J].Surgery，2022，171(2)：518-525.DOI：10.1016/j.surg.2021.05.051.
[26]	Aloird J，Martinaud C，Pasquier P．First transfusion of cold-stored low-titer group O whole blood in the French armed forces[J].Transfusion，2022，62(6)：1305-1309.DOI：10.1111/trf.16897.
[27]	Hazelton JP, Cannon JW, Zatorski C, et al. Cold-stored whole blood：a better method of trauma resuscitation？[J].J Trauma Acute Care Surg，2019，87(5)：1035-1041.DOI：10.1097/TA.0000000000002471.
[28]	Himmler A，Galarza Armijos ME，Naranjo JR，et al.Is the whole greater than the sum of its parts? The implementation and outcomes of a whole blood program in Ecuador[J].Trauma Surg Acute Care Open，2021，6(1)：e000758.DOI：10.1136/tsaco-2021-000758.
[29]	Gallaher JR，Dixon A，Cockcroft A，et al.Large volume transfusion with whole blood is safe compared with component therapy[J].J Trauma Acute Care Surg，2020，89(1)：238-245.DOI：10.1097/TA.0000000000002687.
[30]	Hazelton JP，Ssentongo AE，Oh JS，et al.Use of cold-stored whole blood is associated with improved mortality in hemostatic resuscitation of major bleeding：a multicenter study[J].Ann Surg，2022，276(4)：579-588.DOI：10.1097/SLA.0000000000005603.
[31]	Hosseinpour H，Magnotti LJ，Bhogadi SK，et al.Time to whole blood transfusion in hemorrhaging civilian trauma patients：there is always room for improvement[J].J Am Coll Surg，2023，237(1)：24-34.DOI：10.1097/XCS.0000000000000715.

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