Advances in the study of the anti-inflammatory activity of Wogonin

doi:10.3877/cma.j.issn.2095-655X.2025.01.003

Abstract

Abstract:

Wogonin, a natural flavonoid compound with significant anti-inflammatory properties,which is primarily derived from the traditional Chinese herb Scutellaria baicalensis (Huangqin). In studies of its anti-inflammatory effects, Wogonin has demonstrated potential in inhibiting inflammatory responses through multiple mechanisms. These mechanisms include suppressing the production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, IL-2 and tumor necrosis factor-alpha (TNF-α), regulating inflammatory signaling pathways such as nuclear factor κB (NF-κB) and mitogen-activated protein kinase(MAPK) pathway, inducing apoptosis of inflammatory cells, and enhancing autophagy to clear damaged cells. Wogonin has shown therapeutic potential in various inflammatory diseases such as rheumatoid arthritis,inflammatory bowel disease, and atherosclerosis. This paper reviews the anti-inflammatory mechanisms of Wogonin and its application prospects in different diseases, providing a theoretical basis for future clinical applications.

Key words: Wogonin, Flavonoid, Anti-inflammatory effect, Inflammatory factor, Signal pathway

Zhongxin Li, Xueying Chen, Lijun Gan. Advances in the study of the anti-inflammatory activity of Wogonin[J]. Chinese Journal of Diagnostics(Electronic Edition), 2025, 13(01): 20-25.

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