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中华诊断学电子杂志 ›› 2021, Vol. 09 ›› Issue (02) : 133 -136. doi: 10.3877/cma.j.issn.2095-655X.2021.02.015

所属专题: 文献

综述

脓毒症诊断及集束化治疗依从性的研究进展
闵玉娣1, 孔令斌2,()   
  1. 1. 100032 北京大学人民医院手术室
    2. 272029 济宁医学院附属医院消化内科
  • 收稿日期:2020-12-02 出版日期:2021-05-26
  • 通信作者: 孔令斌

Research progress of sepsis diagnosis and compliance of bundle treatment

Yudi Min1, Lingbin Kong2,()   

  1. 1. Operating Room, Peking University People′s Hospital, Beijing 100032, China
    2. Department of Gastroenterology, The Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2020-12-02 Published:2021-05-26
  • Corresponding author: Lingbin Kong
引用本文:

闵玉娣, 孔令斌. 脓毒症诊断及集束化治疗依从性的研究进展[J]. 中华诊断学电子杂志, 2021, 09(02): 133-136.

Yudi Min, Lingbin Kong. Research progress of sepsis diagnosis and compliance of bundle treatment[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(02): 133-136.

脓毒症是导致住院患者死亡的重要原因之一,及时诊断和治疗是降低脓毒症患者死亡率的重要措施。通过系统检索国内外发表的脓毒症相关文献,对脓毒症的定义、诊断标准、生物学标志物以及集束化治疗进行综述,对近年来脓毒症诊断标准的变迁及新型生物学标志物进行总结,并提出改善脓毒症集束化治疗依从性的干预措施,以期为脓毒症早期诊断及治疗提供参考。

Sepsis is one of the important causes of death in hospitalized patients, and timely diagnosis and treatment are important measures to reduce the mortality of patients with sepsis. Through a systematic search of sepsis-related literatures published at home and abroad, the definition, diagnostic criteria, biological markers, and bundle treatment of sepsis are reviewed, and the evolution of diagnostic criteria and new biological markers of sepsis in recent years are summarized. This paper is to propose intervention measures to improve the compliance of sepsis bundle treatment, in order to provide reference for the early diagnosis and treatment of sepsis.

[1]
Rhodes A, Evans LE, Alhazzani W, et al.Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016[J]. Intensive Care Med, 2017, 43(3): 304-377.
[2]
Teggert A, Datta H, Ali Z. Biomarkers for point-of-care diagnosis of sepsis[J]. Micromachines(Basel), 2020, 11(3): 286-316.
[3]
Bone RC, Sibbald WJ, Sprung CL.The ACCP-SCCM consensus conference on sepsis and organ failure[J]. Chest, 1992, 101(6): 1481-1483.
[4]
姚咏明,盛志勇,林洪远,等.2001年国际脓毒症定义会议关于脓毒症诊断的新标准[J].中国危重病急救医学,2006,18(11):645-646.
[5]
杨建钢,王旭,杨玉彬,等.从脓毒症诊治观念变迁看肾上腺皮质激素的应用[J/CD].中华诊断学电子杂志,2019,7(1):1-6.
[6]
Levy MM, Fink MP, Marshall JC, et al.2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference[J]. Crit Care Med, 2003, 31(4): 1250-1256.
[7]
陈晓洁,董天皞,张桂萍,等.脓毒症定义和诊断标准的演进[J].医学综述,2017,23(16):3230-3235.
[8]
Singer M, Deutschman CS, Seymour CW, et al.The third international consensus definitions for sepsis and septic shock(Sepsis-3)[J]. JAMA, 2016, 315(8): 801-810.
[9]
Póvoa P, Coelho L, Almeida E, et al.Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study[J]. Crit Care, 2006, 10(2): 63-70.
[10]
Simon L, Gauvin F, Amre DK, et al. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis[J]. Clin Infect Dis, 2004, 39(2): 206-217.
[11]
秦晋铝.肝素结合蛋白检测对脓毒症诊断的临床研究[D] .西安:西安医学院,2018.
[12]
Wu Y, Wang F, Fan X, et al.Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis[J]. Crit Care, 2012, 16(6): 229-240.
[13]
Dimoula A, Pradier O, Kassengera Z, et al.Serial determinations of neutrophil CD64 expression for the diagnosis and monitoring of sepsis in critically ill patients[J]. Clin Infect Dis, 2014, 58(6): 820-829.
[14]
周燕南,慕婉晴,顾国嵘,等.Presepsin应用于脓毒症诊断和预后评估的研究进展[J].中国临床医学,2019,26(4):647-652.
[15]
Masson S, Caironi P, Spanuth E, et al.Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the albumin italian outcome sepsis trial[J]. Crit Care, 2014, 18(1): 6-14.
[16]
孙燕燕,王会峰,胡小芮,等.血清Presepsin、PCT、CRP联合检测在脓毒症诊断中的价值[J].宁夏医学杂志,2019,41(7):594-597.
[17]
Mihajlovic D, Brkic S, Lendak D, et al.Endothelial biomarkers in the light of new sepsis definition[J]. Biomark Med, 2019, 13(5): 341-351.
[18]
赵蓉,董士民.血清endocan和降钙素原对脓毒症早期诊断及预后评估的临床价值[J].中华危重病急救医学,2017,29(4):321-326.
[19]
徐莎,肖俊.儿童细菌性脓毒症中富含组氨酸糖蛋白血浆浓度及其诊断价值[J].临床与病理杂志,2019,39(11):2483-2487.
[20]
周增丁,郇京宁.脓毒症诊断生物标志物和诊断方法的临床应用[J].中华创伤杂志,2016,32(10):887-892.
[21]
Abe T, Ogura H, Shiraishi A, et al.Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study[J]. Crit Care, 2018, 22(1): 322-333.
[22]
Lynn NB, Gupta C, Vaaler M, et al.Severe sepsis 3-hour bundle compliance and mortality[J]. Am J Infect Control, 2018, 46(11): 1299-1300.
[23]
Green S, Smith MTD, Kong VY, et al.Compliance with the surviving sepsis campaign guidelines for early resuscitation does not translate into improved outcomes in patients with surgical sepsis in South Africa[J]. S Afr J Surg, 2019, 57(4): 8-12.
[24]
张爽,赵英萍,陈炎堂.严重脓毒症和脓毒性休克病人早期集束化治疗依从性对病死率的影响[J].河北医学,2011,17(7):862-865.
[25]
Chan J, Leung E. A retrospective study on the compliance with surviving sepsis ampaign guideline in patients with sepsis admitted to intensive care unit in Hong Kong[J]. J Intensive Crit Care, 2017, 4(3): 1-10.
[26]
Liu CC, Hsieh WA, Lai PF, et al.Emergency physician compliance with quality indicators of septic shock and severe sepsis in Eastern Taiwanese community hospital[J]. J Acute Med, 2017, 7(4): 135-140.
[27]
Breen SJ, Rees S. Barriers to implementing the sepsis six guidelines in an acute hospital setting[J]. Br J Nurs, 2018, 27(9): 473-478.
[28]
Kakebeeke D, Vis A, de Deckere ER, et al. Lack of clinically evident signs of organ failure affects ED treatment of patients with severe sepsis[J]. Int J Emerg Med, 2013, 6(1): 4-12.
[29]
Kang MJ, Shin TG, Jo IJ, et al.Factors influencing compliance with early resuscitation bundle in the management of severe sepsis and septic shock[J]. Shock, 2012, 38(5): 474-479.
[30]
Roberts N, Hooper G, Lorencatto F, et al.Barriers and facilitators towards implementing the sepsis six care bundle (BLISS-1): a mixed methods investigation using the theoretical domains framework[J]. Scand J Trauma Resusc Emerg Med, 2017, 25(1): 96.
[31]
Tarrant C, O'Donnell B, Martin G, et al.A complex endeavour: an ethnographic study of the implementation of the Sepsis six clinical care bundle[J]. Implement Sci, 2016, 11(1): 149-159.
[32]
Kwizera A, Adhikari NKJ, Angus DC, et al.Recognition of sepsis in resource-limited settings[J]. Cham (CH): Springer, 2019(2019): 69-84.
[33]
Gyang E, Shieh L, Forsey L, et al.A nurse-driven screening tool for the early identification of sepsis in an intermediate care unit setting[J]. J Hosp Med, 2015, 10(2): 97-103.
[34]
Bruce HR, Maiden J, Fedullo PF, et al.Impact of nurse-initiated ED sepsis protocol on compliance with sepsis bundles, time to initial antibiotic administration, and in-hospital mortality[J]. J Emerg Nurs, 2015, 41(2): 130-137.
[35]
Arabi YM, Al-Dorzi HM, Alamry A, et al.The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock[J]. Ann Intensive Care, 2017, 7(1): 57-66.
[36]
潘纯,邱海波.改善脓毒症治疗指南依从性:影响因素与应对措施[J/CD].中华重症医学电子杂志,2016,2(1):32-35.
[37]
Peltola L, Goddia C, Namboya F, et al.Sepsis-knowledge of non-physician personnel in Africa: a cross-sectional study in Malawian district hospitals[J]. Med Klin Intensivmed Notfmed, 2015, 110(1): 49-54.
[38]
黄瑞瑜.基于风险矩阵法的ICU成人脓毒性休克护理风险预警研究[D].遵义:遵义医科大学,2018.
[39]
Krzywicki E. Using a clinical guideline coupled with education to improve healthcare providers′ Knowledge of early sepsis recognition in the post-acute care setting: a quality improvement[D]. Arizona: Arizona State University, 2017.
[40]
Kliger J, Singer SJ, Hoffman FH.Using the integrated nurse leadership program to reduce sepsis mortality[J]. Jt Comm J Qual Patient Saf, 2015, 41(6): 264-272.
[41]
Ferguson A, Coates DE, Osborn S, et al.Early, nurse-directed sepsis care[J]. Am J Nurs, 2019, 119(1): 52-58.
[42]
张洁.核查单在感染性休克集束化护理中的应用[J].心理医生,2018,24(3):246-247.
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