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中华诊断学电子杂志 ›› 2021, Vol. 09 ›› Issue (03) : 149 -151. doi: 10.3877/cma.j.issn.2095-655X.2021.03.002

精神疾病诊治

多基因风险分数在精神分裂症预防与预测中的应用与挑战
李俏俊1,(), 吕兴平2, 徐佳圆3, 禚传君4   
  1. 1. 300134 天津商业大学信息工程学院
    2. 300134 天津商业大学理学院
    3. 300052 天津医科大学总医院医学影像科
    4. 300140 天津市第四中心医院实时脑环路重点实验室
  • 收稿日期:2021-02-26 出版日期:2021-08-26
  • 通信作者: 李俏俊
  • 基金资助:
    国家自然科学基金青年项目(81801687)

Application and challenge of polygenic risk score in prevention and prediction of schizophrenia

Qiaojun Li1,(), Xingping Lyu2, Jiayuan Xu3, Chuanjun Zhuo4   

  1. 1. School of Information Engineering, Tianjin University of Commerce, Tianjin 300134, China
    2. School of Science, Tianjin University of Commerce, Tianjin 300134, China
    3. Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China
    4. Key Laboratory of Real-time Brain Circuits, Tianjin Fourth Center Hospital, Tianjin 300140, China
  • Received:2021-02-26 Published:2021-08-26
  • Corresponding author: Qiaojun Li
引用本文:

李俏俊, 吕兴平, 徐佳圆, 禚传君. 多基因风险分数在精神分裂症预防与预测中的应用与挑战[J]. 中华诊断学电子杂志, 2021, 09(03): 149-151.

Qiaojun Li, Xingping Lyu, Jiayuan Xu, Chuanjun Zhuo. Application and challenge of polygenic risk score in prevention and prediction of schizophrenia[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(03): 149-151.

精神分裂症是遗传度较高的复杂性疾病,基于候选基因研究和全基因组关联分析两种方法,已发现众多与之相关的易感性位点。近年来,多基因风险分数(PRS)可以在对精神分裂症风险人群进行初步的诊断、鉴别、预测等方面中发挥重要的辅助作用,并且为今后的精神分裂症潜在人群的早期预防和治疗提供重要助力。笔者就精神分裂症预防与预测中PRS的应用与挑战进行论述。

Schizophrenia is a complex disease with high heritability. Many susceptibility loci have been found in candidate genes and genome-wide association studies. Recently, polygenic risk score (PRS) has been playing an important role in the diagnosis, discrimination, and prediction of schizophrenia. Also, PRS could provide important assistance for the early prevention and treatment of potential schizophrenics in the future. This article discusses the application and challenges of PRS in the prevention and prediction of schizophrenia.

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