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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (02) : 82 -86. doi: 10.3877/cma.j.issn.2095-655X.2023.02.003

感染性疾病诊治

肠道菌群与抗结核药及其所致肝损伤的相关性研究进展
刘艳1, 唐神结2,()   
  1. 1. 215400 苏州大学附属太仓医院(太仓市第一人民医院)感染科
    2. 101149 首都医科大学附属北京胸科医院(北京市结核病胸部肿瘤研究所)临床医学中心
  • 收稿日期:2022-03-19 出版日期:2023-05-04
  • 通信作者: 唐神结
  • 基金资助:
    北京市临床重点专科项目(20201214)

Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury

Yan Liu1, Shenjie Tang2,()   

  1. 1. Department of Infectious Disease, Taicang Affiliated Hospital of Soochow University, the First People′s Hospital of Taicang, Taicang 215400, China
    2. Clinical Medicine Center, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Affiliated to Capital Medical University, Beijing 101149, China
  • Received:2022-03-19 Published:2023-05-04
  • Corresponding author: Shenjie Tang
引用本文:

刘艳, 唐神结. 肠道菌群与抗结核药及其所致肝损伤的相关性研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 82-86.

Yan Liu, Shenjie Tang. Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 82-86.

结核病是结核分枝杆菌引起的严重危害人类健康的慢性传染病,有效的抗结核治疗是遏制其流行的关键。肠道菌群作为人类"第二基因组",其稳态对维持人体健康十分重要。抗结核药物属于抗生素类药品,可导致肠道菌群的失衡,失衡的肠道菌群又与抗结核药物性肝损伤密切相关,并可影响治疗的效果与疾病的转归。笔者主要就抗结核药对肠道菌群的影响、抗结核药所致肠道菌群失调与肝损伤、肠道菌群的改变对宿主的影响3个方面进行综述。

The bacteria mycobacterium tuberculosis is the primary cause of tuberculosis, a deadly chronic infectious disease. Effective antituberculous therapy is essential for controlling the tuberculosis epidemic. Since the intestinal flora serves as the " second genome" of humans, maintaining its equilibrium is critical for maintaining good health. Antibiotics, which are commonly used to treat tuberculosis, may disturb the equilibrium of the intestinal flora. Intestinal flora imbalance has been linked to liver damage caused by antituberculosis drugs, and it can influence how well treatments work and how the disease develops. This paper discusses the impact of antituberculosis medications on intestinal flora, the imbalance of intestinal flora and liver damage caused by antituberculosis medications, and the repercussions of changes in intestinal flora on the host.

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