切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2026, Vol. 14 ›› Issue (01) : 38 -43. doi: 10.3877/cma.j.issn.2095-655X.2026.01.005

学术动态

中国肺癌磁共振成像从功能性成像到影像组学的诊断演进
汪艺宸1,2, 陈涛1, 周嘉璇1, 李新春1, 万齐1,()   
  1. 1510120 广州医科大学附属第一医院 国家呼吸医学中心放射科
    2511400 广州医科大学第二临床学院
  • 收稿日期:2025-12-06 出版日期:2026-02-26
  • 通信作者: 万齐
  • 基金资助:
    呼吸疾病国家重点实验室(SKLRD-OP-202311); 广东省钟南山医学基金会(ZNS-XS-ZZ-202409-007); 广州市科学技术局基金(2024A03J1229); 广州市卫生健康科技项目(20241A011077)

The diagnostic evolution of magnetic resonance imaging in lung cancer from functional imaging to radiomics in China

Yichen Wang1,2, Tao Chen1, Jiaxuan Zhou1, Xinchun Li1, Qi Wan1,()   

  1. 1Department of Radiology, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
    2Second Clinical Medical College, Guangzhou Medical University, Guangzhou 511400, China
  • Received:2025-12-06 Published:2026-02-26
  • Corresponding author: Qi Wan
引用本文:

汪艺宸, 陈涛, 周嘉璇, 李新春, 万齐. 中国肺癌磁共振成像从功能性成像到影像组学的诊断演进[J/OL]. 中华诊断学电子杂志, 2026, 14(01): 38-43.

Yichen Wang, Tao Chen, Jiaxuan Zhou, Xinchun Li, Qi Wan. The diagnostic evolution of magnetic resonance imaging in lung cancer from functional imaging to radiomics in China[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2026, 14(01): 38-43.

目的

探讨过去35年国内磁共振成像(MRI)在肺癌诊断中的研究热点演变与前沿趋势。

方法

检索中国知网、万方、维普三大中文数据库1991-01-01至2025-12-31发表的相关文献。运用NoteExpress进行筛选与去重,利用CiteSpace、VOSviewer进行文献计量与可视化分析,包括年发文量、机构与作者合作网络、关键词共现与突现分析。

结果

最终纳入文献1 588篇。年发文量总体呈现上升趋势,于2019年达到峰值(111篇)。其中海军军医大学第二附属医院(上海长征医院)是国内发文量最多的机构(34篇)。各高产作者之间存在合作关系,并形成了各自稳定的研究团队,但跨团队合作有限。在机构合作情况中院内、跨机构合作均存在,但顶尖机构之间的合作较少。关键词分析表明,近年来肺癌MRI研究热点从弥散加权成像等功能性成像逐步向病理类型、影像组学演进。

结论

过去35年,国内肺癌MRI研究热点从功能性成像逐渐向影像组学、定量成像、肺结节精准检测、人工智能等前沿领域推进。

Objective

To explore the evolution of research hotspots and cutting-edge trends in magnetic resonance imaging (MRI) for lung cancer diagnosis in China over the past 35 years.

Methods

Literature was retrieved from three major Chinese databases: China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP, published from January 1, 1991, to December 31, 2025. The retrieved literature was screened and deduplicated using NoteExpress. Bibliometric and visual analyses, including annual publication volume, institutional and author collaboration networks, as well as keyword co-occurrence and burst analysis, were conducted using CiteSpace and VOSviewer.

Results

A total of 1 588 articles were eventually included. The annual publication volume showed an overall upward trend, peaking in 2019 with 111 articles. Among them, the second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital) was the institution with the highest domestic publication output (34 articles). High-yield authors demonstrated collaborative relationships and formed their own stable research teams, yet cross-team collaborations remained limited. In terms of institutional collaboration, both intra-institutional and cross-institutional cooperation existed, but collaborations among top-tier institutions were relatively scarce. Keyword analysis indicated that in recent years, the research focus of MRI in lung cancer had gradually evolved from functional imaging such as diffusion-weighted imaging to pathological types and radiomics.

Conclusion

Over the past 35 years, research hotspots on MRI in lung cancer have gradually shifted from functional imaging to cutting-edge fields such as radiomics, quantitative imaging, precise detection of pulmonary nodules, and artificial intelligence.

图1 文献筛选流程图
图2 肺癌磁共振研究领域1991—2025年发文量变化趋势
表1 肺癌磁共振研究领域的机构发文量情况
图3 肺癌磁共振研究领域的作者合作网络图注:人名字号大小与作者在该领域的发文量成正比,字号越大表示发文量越多;连线颜色与合作文章发表时间相关,颜色越深代表发文时间越早
表2 肺癌磁共振研究领域的关键词词频分析
图4 肺癌磁共振研究领域的关键词共现聚类图注:不同颜色代表不同聚类;节点间连线的粗细表示联系的密切程度,连线越多,关系越密切
图5 肺癌磁共振研究领域的被引频次激增强度排名前19的关键词注:红色线段表示该关键词出现的最强时间段
[1]
Bray FLaversanne MSung H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin202474(3):229-263.DOI:10.3322/caac.21834.
[2]
中华医学会放射学分会青年学组,中华医学会放射学分会心胸学组,中华医学会放射学分会磁共振学组.肺部MRI检查和评估专家共识[J].中华放射学杂志202559(6):625-634.DOI:10.3760/cma.j.cn112149-20250120-00043.
[3]
万齐,李新春.肺实性结节MRI成像技术与影像诊断[J].中华放射学杂志202559(12):1447-1452.DOI:10.3760/cma.j.cn112149-20250829-00511.
[4]
Wu TWu LChen Y,et al.Global trends and developments in pulmonary magnetic resonance imaging research:a bibliometric analysis of the past decade[J].Quant Imaging Med Surg202515(5):4431-4444.DOI:10.21037/qims-24-2205.
[5]
Azour LOhno YBiederer J,et al.Lung MRI:indications,capabilities,and techniques-AJR expert panel narrative review[J].AJR Am J Roentgenol2025225(4):e2532637.DOI:10.2214/AJR.25.32637.
[6]
Wu LGao CWu T,et al.Magnetic resonance imaging in the clinical evaluation of lung disorders:current status and future prospects[J].J Magn Reson Imaging202562(5):1260-1279.DOI:10.1002/jmri.29802.
[7]
Pan FFeng LLiu B,et al.Application of radiomics in diagnosis and treatment of lung cancer[J].Front Pharmacol2023(14):1295511.DOI:10.3389/fphar.2023.1295511.
[8]
赵传,姜鲁宁,李岷,等.晚期非小细胞肺癌诊断及呼吸康复治疗的研究进展[J/CD].中华诊断学电子杂志20219(3):211-216.DOI:10.3877/cma.j.issn.2095-655X.2021.03.016.
[9]
姜云珠,张进,陈明,等.基于MRI 3D-T1WI增强影像组学模型预测非小细胞肺癌脑转移EGFR基因突变状态[J].临床放射学杂志202241(7):1212-1216.DOI:10.13437/j.cnki.jcr.2022.07.003.
[10]
Sun SBesson FLZhao B,et al.Toward radiomics for assessment of response to systemic therapies in lung cancer[J].Oncotarget202011(51):4677-4680.DOI:10.18632/oncotarget.27847.
[11]
范丽,夏艺,刘士远.肺部磁共振成像机遇与挑战——中国十年来发展成果及展望[J].磁共振成像202213(10):61-65.DOI:10.12015/issn.1674-8034.2022.10.008.
[12]
张玮,赵鹏,郭文秀,等.基于T1 mapping序列的定量参数鉴别肺癌病理类型的应用研究[J].磁共振成像202314(12):33-39,48.DOI:10.12015/issn.1674-8034.2023.12.006.
[13]
Jiang JXiao YLiu J,et al.T1 mapping-based radiomics in the identification of histological types of lung cancer:a reproducibility and feasibility study[J].BMC Med Imaging202424(1):308.DOI:10.1186/s12880-024-01487-y.
[14]
汪玉,林祥涛,杨咏青,等.ZOOMit IVIM和T1 mapping成像在诊断肺良恶性病变中的应用[J].医学影像学杂志202333(9):1585-1588,1593.
[15]
Li GHuang RZhu M,et al.Native T1-mapping and diffusion-weighted imaging (DWI) can be used to identify lung cancer pathological types and their correlation with Ki-67 expression[J].J Thorac Dis202214(2):443-454.DOI:10.21037/jtd-22-77.
[16]
Jiang JCui LXiao Y,et al.B1-corrected T1 mapping in lung cancer:repeatability,reproducibility,and identification of histological types[J].J Magn Reson Imaging202154(5):1529-1540.DOI:10.1002/jmri.27844.
[17]
Ohno YTakenaka DYoshikawa T,et al.Efficacy of ultrashort echo time pulmonary MRI for lung nodule detection and lung-RADS classification[J].Radiology2022302(3):697-706.DOI:10.1148/radiol.211254.
[18]
Bae KJeon KNHwang MJ,et al.Comparison of lung imaging using three-dimensional ultrashort echo time and zero echo time sequences:preliminary study[J].Eur Radiol201929(5):2253-2262.DOI:10.1007/s00330-018-5889-x.
[19]
Cavion CCAltmayer SForte GC,et al.Diagnostic performance of MRI for the detection of pulmonary nodules:a systematic review and meta-analysis[J].Radiol Cardiothorac Imaging20246(2):e230241.DOI:10.1148/ryct.230241.
[20]
Zou QWan QLiu J,et al.Image quality and detection efficacy of zero echo time magnetic resonance imaging on Lung-RADS 2 pulmonary ground-glass nodules in comparison to thin-slice fat-saturated T2-weighted imaging[J].J Thorac Dis202416(8):5167-5179.DOI:10.21037/jtd-24-414.
[21]
Cao P, Jia X, Wang X, et al. Deep learning radiomics for the prediction of epidermal growth factor receptor mutation status based on MRI in brain metastasis from lung adenocarcinoma patients[J].BMC Cancer202525(1):443.DOI:10.1186/s12885-025-13823-8.
[22]
张哲尧,徐凯.深度学习在医学影像学中的国内研究新趋势:基于CiteSpace的科学计量分析[J].放射学实践202439(9):1233-1237.DOI:10.13609/j.cnki.1000-0313.2024.09.018.
[1] 侯超, 夏纪筑, 李明星, 何文, 张巍. TCS-MR融合成像揭示帕金森病黑质高回声的空间分布特征[J/OL]. 中华医学超声杂志(电子版), 2025, 22(10): 944-954.
[2] 王江坤, 唐棣, 邱伟明, 王淞. 基于CiteSpace的增生性瘢痕研究热点及发展趋势的可视化分析[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(06): 510-518.
[3] 翟羽翔, 陈仁吉. 语音治疗对非综合征型唇腭裂言语障碍患者大脑神经网络影响的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(06): 418-423.
[4] 李洁, 孙培伟, 胡婉珍, 曾舜, 陆漪琳, 刘忠. 进展期胃癌生物标志物研究热点的文献计量学可视化分析[J/OL]. 中华普通外科学文献(电子版), 2025, 19(06): 376-382.
[5] 杨雯林, 吴元魁. 影像组学在胰腺神经内分泌瘤诊疗中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2025, 19(06): 426-432.
[6] 毛俊, 蔡兆伦, 尹晓南, 沈朝勇, 张波. 影像组学预测模型在胃肠间质瘤诊断及预后中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2025, 19(06): 421-425.
[7] 戴宗伯, 张城硕, 郭庭维, 何知远, 赵昊宇, 张宇慈, 张佳林. 基于MRI影像组学机器学习构建肝细胞癌微血管侵犯预测模型[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(01): 36-44.
[8] 何泰霖, 王峻峰, 田林云, 王罡, 杨超, 王海峰. 基于CT影像组学构建肝细胞癌微血管侵犯预测模型[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(01): 45-52.
[9] 钟文卿, 韩冰. 基于术前CT影像数据构建肝癌患者生存期Nomogram预测模型[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(01): 53-58.
[10] 黄少坚, 梁汉标, 李清平, 唐善华, 李青妍, 李芷西, 黄灿, 王小振, 陈灿辉, 王恺, 李川江. 基于影像组学和临床特征构建肝癌新辅助/转化治疗后病理学完全缓解预测模型[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(06): 860-867.
[11] 刘郁芳, 赵青. 直肠癌MRI影像学评估:从精准分期到预后预测的研究进展与展望[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(01): 31-36.
[12] 孙钢. 零液氦磁共振成像系统的发展现状和展望[J/OL]. 中华消化病与影像杂志(电子版), 2026, 16(01): 1-5.
[13] 胡斌, 柳林. 食管癌新辅助治疗后CT影像特征变化与术后病理完全缓解率的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(06): 627-634.
[14] 赵欣, 李昊昌, 赵海玥, 房秀霞, 卫星彤. 超声联合X线摄影和MRI对肿块型和非肿块型乳腺病变的诊断价值[J/OL]. 中华临床医师杂志(电子版), 2025, 19(10): 758-766.
[15] 林净净, 韩佳育, 成官迅, 李世峰. 基于ABIDE数据库的孤独症谱系障碍小脑形态自动分割与多中心验证[J/OL]. 中华诊断学电子杂志, 2026, 14(01): 24-30.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?