To study the expression level and significance of serum human protease serine 8(PRSS8) in the patient with gastritis, esophagitis and esophageal cancer.

The serum samples from healthy subjects and the patients diagnosed as esophagitis, esophageal cancer and gastritis were collected.The serum samples included 20 esophagitis serum samples, 6 esophageal cancer serum samples, 60 gastritis serum samples and 28 healthy serum samples.The expression level of PRSS8 was detected by ELISA assay.Then the serum PRSS8 levels from the esophagitis group, esophageal cancer group and the gastritis group were compared with the healthy group, respectively.

The serum level of PRSS8 in esophagitis group [(4.58±1.67)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was statistically significant(LSD-t=2.59, P<0.05). The serum level of PRSS8 in esophageal cancer group [(5.05±0.57)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was statistically significant(LSD-t=2.54, P<0.05). The serum level of PRSS8 in esophageal cancer group [(5.05±0.57)μg/L] was higher than that from the esophagitis group [(4.58±1.67)μg/L], the difference was not statistically significant(LSD-t=0.83, P>0.05). The level of serum PRSS8 in gastritis group [(5.39±1.04)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was also statistically significant (LSD-t=6.22, P<0.05).

Serum PRSS8 expression levels are obviously increased in the patients with esophagitis, esophageal cancer and gastritis, which suggests that serum PRRS8 maybe relate to the development of esophagitis, esophageal cancer and gastritis.