To explore the clinical application value of heart fatty acid binding protein (h-FABP) combined with echocardiographic circumferential strain on early diagnosis of non ST segment elevation myocardial infarction (NSTEMI).

A total of 111 patients with acute chest pain within 3 hours who underwent coronary angiography were selected in cardiology of the First Hospital of Shanxi Medical University from December 2015 to December 2016.Serum levels of h-FABP and cardiac troponin I (cTnI) were measured immediately after admission.The left ventricular circumferential strain(CS) of 17 segments was determined by echocardiographic two-dimensional speckle tracking imaging(2D-STI), and the left ventricular global circumferential strain (GCS) was calculated simultaneously.According to the results of coronary angiography, cTnI level 6h after admission and ECG manifestation, patients were divided into 2 groups: 71 cases in NSTEMI group and 40 cases in the normal control group.

The cTnI level of NSTEMI group [(0.58±0.71)μg/L] was higher than that of control group [(0.43±0.63)μg/L], the difference was not statistically significant (t=1.10, P>0.05). The levels of H-FABP [(NSTEMI group: (5.59±2.76)μg/L, control group (1.79±2.39)μg/L], GCS [(NSTEMI group: (-15.80±2.33)%, control group: (-18.89±2.50)%] in NSTEMI group were significantly higher than those in the control group (t=7.30, 6.54; P<0.05). The area under the receiver operating characteristic (ROC) curve of h-FABP in the early diagnosis of NSTEMI was 0.851, the area under the ROC curve of GCS in the early diagnosis of NSTEMI was 0.854, the area under the ROC curve of combining h-FABP with GCS in the early diagnosis of NSTEMI was 0.916.Joint detection of H-FABP+ GCS was better than single detection in the early diagnosis of NSTEMI.

Combining serum level of h-FABP with echocardiographic GCS can improve the early diagnostic rate of NSTEMI.