To explore the clinical, pathological and imaging features of Ewing′s sarcoma in lumbar and to improve the understanding and diagnosis rate of the disease.

Laboratory tests, computed tomography (CT), magnetic resonance imaging (MRI), pathological examination of one patient with Ewing′s sarcoma in lumbar were analyzed and the related literatures were reviewed.

Expect the level of Neuron Specific Enolization Enzyme was 111.30 μg/L, the rest of the laboratory test results were normal.The X-ray demonstrated T₅ vertebral wedge deformation and adjacent gap narrowed.CT results showed T₅ vertebral wedge deformation and local bone kyphosis.MRI results revealed multiple vertebral destruction, and local soft tissue mass formation.Immunohistochemical results: S-100, synuclein(Syn), proliferation index (Ki-67), FLI-1 were partial positive, vimentin(Vim), CD99, CD56 were positive, creatine kinase (CK), CD3, CD20, thyroid transcription factor-1(TTF-1), myeloperoxidase(MPO), CD34, terminal deoxynucleotidyl transferase(TdT), chromogranin A (CgA), CD7, CD38, B-cell specific activator protein(PAX-5), CD138, CD79a, CK8/18 were negative.Finally, pathological diagnosis of Ewing′s sarcoma were made.

Ewing′s sarcoma is characterized by short duration, early widespread metastases and poor prognosis.The disease can be diagnosed by clinical and imageological examination.