Diagnostic value of serum N-epsilon-carboxy methyl lysine levels in patients with acute coronary syndrome

doi:10.3877/cma.j.issn.2095-655X.2017.04.002

Abstract

Abstract:

Objective

To investigate the diagnostic value of N-epsilon-carboxy methyl lysine (CML) in patients with acute coronary syndrome (ACS).

Methods

A total of 160 patients who were hospitalized from department of cardiology, Jiangsu University affiliated hospital (120 patients) and department of cardiology, Jintan Hospital affiliated to Jiangsu University (40 patients) were divided into control group (group A, n=40), unstable angina pectoris group (group B, n=40), non-ST-segment elevation myocardial infarction group (group C, n=40) and ST-segment elevation myocardial infarction group (group D, n=40). All patients received venous blood after admission.Serum CML and cardiac troponin I (cTnI) levels were detected respectively.

Results

The serum levels of CML in patients with ACS were significantly higher than that in group A [(183.82±57.65)μg/L], the increased levels of CML in group C [(806.48±38.60) μg/L]and group D [(869.37±73.61)μg/L] were significantly higher than that in group B [(538.25±48.46)μg/L; F=1238.71, P<0.01]. Besides, the expression of CML was positively correlated with coronary Gensini score (r= 0.43, P<0.05), and the increased CML level in coronary artery was significantly correlated with the severity of coronary artery lesion.The difference among coronary lesion vessels was statistically significant [single-branch vessel (494.08±56.13)μg/L, double-branch vessel (547.17±43.47)μg/L, three-branch vessel (622.21±42.48)μg/L, F=41.15, P<0.05].

Conclusions

The level of CML is closely related to the severity of coronary artery disease and it may be used as a complement factor to cTnI in the diagnosis of acute coronary syndrome.

Key words: N-epsilon-carboxy methyl lysine, Cardiac troponin I, Acute coronary syndrome

Yingpeng Ding, Wenmin Yu, Lei Zhou, Yuan Lyu, Rongzeng Du, Zhongqun Wang. Diagnostic value of serum N-epsilon-carboxy methyl lysine levels in patients with acute coronary syndrome[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(04): 221-224.

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References 14

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项目	A组(n＝40)	B组(n＝40)	C组(n＝40)	D组(n＝40)	统计量	P值
男/女(例)	20/20	20/20	20/20	20/20	χ²＝1.00	>0.05
年龄(岁，±s)	65.06±11.38	64.21±10.46	62.34±8.97	63.34±10.31	F＝0.24	>0.05
高血压病(例，%)	17(42.50)	25(62.50)	27(67.50)	29(72.50)	χ²＝0.03	<0.05
糖尿病(例，%)	3(7.50)	9(22.50)	11(27.50)	13(32.50)	χ²＝0.05	<0.05
吸烟(例，%)	5(12.50)	7(17.50)	12(30.00)	15(37.50)	χ²＝0.04	<0.05
低密度脂蛋白胆固醇(mmol/L，±s)	2.87±0.15	3.42±0.21	3.33±0.17	3.34±0.11	F＝0.00	<0.05

项目	A组(n＝40)	B组(n＝40)	C组(n＝40)	D组(n＝40)	统计量	P值
男/女(例)	20/20	20/20	20/20	20/20	χ²＝1.00	>0.05
年龄(岁，±s)	65.06±11.38	64.21±10.46	62.34±8.97	63.34±10.31	F＝0.24	>0.05
高血压病(例，%)	17(42.50)	25(62.50)	27(67.50)	29(72.50)	χ²＝0.03	<0.05
糖尿病(例，%)	3(7.50)	9(22.50)	11(27.50)	13(32.50)	χ²＝0.05	<0.05
吸烟(例，%)	5(12.50)	7(17.50)	12(30.00)	15(37.50)	χ²＝0.04	<0.05
低密度脂蛋白胆固醇(mmol/L，±s)	2.87±0.15	3.42±0.21	3.33±0.17	3.34±0.11	F＝0.00	<0.05

组别	例数	cTnI	CML
单支病变	72	2.56±1.61	494.08±56.13
双支病变	34	6.14±3.82	547.17±43.47
3支病变	14	9.79±5.00	622.21±42.48
F值	?	44.22	41.15
P值	?	<0.01	<0.01

组别	例数	cTnI	CML
单支病变	72	2.56±1.61	494.08±56.13
双支病变	34	6.14±3.82	547.17±43.47
3支病变	14	9.79±5.00	622.21±42.48
F值	?	44.22	41.15
P值	?	<0.01	<0.01

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