Research situation of tau proteins and β-amyloid protein in the pathological process and autophagic mechanisms in Alzheimer′s disease

doi:10.3877/cma.j.issn.2095-655X.2019.02.005

Abstract

Abstract:

Alzheimer′s disease(AD) is a neurodegenerative disease which is the most common form of dementia in the elderly. Misfolding and accumulation of tau proteins and β-amyloid (Aβ) (1-42) cause progressive neuronal loss. In recent researches, the biological markers of AD, tau proteins and β-amyloid protein, could reflect its pathological features as including neuronal fiber tangles (NFTs) and senile plaque (SP) deposition in neurons. Autophagy is a highly conserved lysosomal-dependent degradation process that supplies energy to the body, cleans up metabolic waste, and balances immune inflammatory responses.In this review, we concluded the pathology of tau proteins and Aβ protein and the autophagic mechanisms in AD.

Key words: Alzheimer disease, Tau proteins, Amyloid, Pathology, Autophagy

Lei Qiao, Yinyi Sun, Zhongsen Qu. Research situation of tau proteins and β-amyloid protein in the pathological process and autophagic mechanisms in Alzheimer′s disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 94-97.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhzdxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-655X.2019.02.005

https://zhzdxdzzz.cma-cmc.com.cn/EN/Y2019/V07/I02/94

Figures/Tables 2

References 33

[1]	Yilmaz U．Alzheimer′s disease[J]．Radioloqe，2015，55(5):386-388.
[2]	宋昕，洪羽蓉，胡秋莹. 阿尔兹海默病发病原因及机制的研究进展[J]．临床和实验医学杂志，2015, 14(10):871-873.
[3]	Wang JZ, Gong CX, Zaidi T，et al.Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B[J]．J Biol Chem，1995，270(9):4854-4860.
[4]	陈杨剑侠，柯尊记．自噬在阿尔兹海默病防治中的作用[J]．饮食保健，2018，5(7):296-297.
[5]	Wenk GL.Neuropathologic changes in Alzheimer′s disease[J]．J Clin Psychiatry，2003，64(Suppl9):7-10.
[6]	Sjögren M, Davidsson P, Gottfries J，et al. The cerebrospinal fluid levels of tau，growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer′s disease，reflecting a common pathophysiological process[J]. Dement Geriatr Cogn Disord，2001，12(4):257-264.
[7]	Neve RL, Harris P, Kosik KS，et al.Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2[J]．Brain Res，1986，387(3):271-280.
[8]	Goedert M, Rutherford RD, Crowther RA.Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2[J]．Neuron，1989(3):519-526.
[9]	Scott CW, Blowers DP, Barth PT，et al.Differences in the abilities of human tau isoforms to promote microtubule assembly[J]．Neurosci Res，1991，30(1):154-162.
[10]	Trinczek B, Biernat J, Baumann K，et al.Domains of tau protein，differential phosphorylation，and dynamic instability of microtubules[J]．Mol Biol Cell，1995，6(12):1887-1902.
[11]	Kins S, Kurosinski P, Nitsch RM，et al.Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice[J]．Am J Pathol，2003，163(3):833-843.
[12]	An WL, Cowburn RF, Li L，et al.Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer′s disease[J]．Am J Pathol，2003，163(2):591-607.
[13]	Spillantini MG, Murrell JR, Goedert M，et al.Mutation in the tau gene in familial multiple system tauopathy with presenile dementia[J]．Proc Natl Acad Sci USA，1998，95(13):7737-7741.
[14]	Jadhav S, Cubinkova V, Zimova I，et al.Tau-mediated synaptic damage in Alzheimer′s disease[J]. Transl Neurosci，2015，6(1):214-226.
[15]	Sontag E, Nunbhakdi-Craig V, Lee G，et al.Molecular interactions among protein phosphatase 2A, tau, and microtubules.Implications for the regulation of tau phosphorylation and the development of tauopathies[J]．J Biol Chem，1999，274(36):25490-25498.
[16]	Davidsson P, Sjögren M. The use of proteomics in biomarker discovery in neurodegenerative diseases[J]．Dis Markers，2005，21(2):81-92.
[17]	Huang HC, Jiang ZF.Accumulated amyloid-β peptide and hyperphosphorylated tau protein：relationship and links in alzheimer′s disease[J]．J Alzheimers Dis，2009，16(1):15-27.
[18]	Hardy JA, Higgins GA.Alzheimer′s disease：the amyloid cascade hypothesis[J]．Science，1992，256(5054):184-185.
[19]	Blennow K, Mattsson N, Schöll M，et al.Amyloid biomarkers in Alzheimer′s disease[J]．Trends Pharmacol Sci，2015，36(5):297-309.
[20]	Tamaoka A. The pathophysiology of Alzheimer′s disease with special reference to "amyloid cascade hypothesis" [J]．Rinsho Byori，2013，61(11):1060-1069.
[21]	Luo J, Wärmländer SK, Gräslund A, et al. Alzheimer peptides aggregate into transient nanoglobules that nucleate fibrils[J]．Biochemistry，2014，53(40):6302-6308.
[22]	冯利杰，张瑾，丁倩，等．自噬参与神经细胞中过表达tau和异常磷酸化tau蛋白的降解[J]．中国药理学通报，2015，31(3):356-362.
[23]	Klionsky DJ, Abdelmohsen K, Abe A，et al.Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)[J]．Autophagy，2016，12(1):1-222.
[24]	Friedman LG, Qureshi YH, Yu WH.Promoting autophagic clearance：viable therapeutic targets in alzheimer′s disease[J]．Neurotherapeutics，2015，12(1):94-108.
[25]	Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer′s disease Aβ peptide[J]．Bioessays，2014，36(6):570-578.
[26]	Jewell JL, Russell RC, Guan KL.Amino acid signalling upstream of mTOR[J] .Nat Rev Mol Cell Biol，2013，14(3):133-139.
[27]	Nilsson P, Saido TC. Dual roles for autophagy：degradation and secretion of Alzheimer′s disease Aβ peptide [J]．BioEssays，2014，36(6):570-578.
[28]	Steele JW, Lachenmayer ML, Ju S, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer′s mouse model[J]．Mol Psychiatry，2013，18(8):889-897.
[29]	Sweetlove M．Phase Ⅲ concert trial of latrepirdine[J] .Pharmaceut Med，2012，26(2):113-115.
[30]	Zhu Z, Yan J, Jiang W，et al.Arctigenin effectively ameliorates memory impairment in Alzheimer′s disease model mice targeting both β-Amyloid production and clearance[J]．J Neurosci，2013，33(32):13138-13149.
[31]	Darlington D, Deng J, Giunta B，et al.Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice[J]．Stem Cells Dev，2012，22(3):412-421.
[32]	Kirkin V, McEwan DG, Novak I，et al.A role for ubiquitin in selective autophagy[J]．Mol cell，2009，34(3):259-269.
[33]	李伟，肖世富．阿尔茨海默病诊断标准的演变及评价[J/CD]．中华诊断学电子杂志，2015，3(2):114-117.

Please choose a citation manager

Content to export