Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Diagnostics(Electronic Edition) ›› 2019, Vol. 07 ›› Issue (02): 98-102. doi: 10.3877/cma.j.issn.2095-655X.2019.02.006

Special Issue:

• Cognitive Disorders • Previous Articles     Next Articles

Research situation on the role of glycogen synthase kinase-3β in the pathogenesis and treatment of Alzheimer′s disease

Mengyang Zhang1, Yue Wang2,()   

  1. 1. Clinical College, Capital Medical University, Beijing 100069, China
    2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2018-11-14 Online:2019-05-26 Published:2019-05-26
  • Contact: Yue Wang
  • About author:
    Corresponding author: Wang Yue, Email:

Abstract:

Alzheimer disease (AD) is the most common age-related senile dementia. Senile plaques and neurofibrillary tangles are two histopathological hallmarks of this disease. Glycogen synthase kinase-3β(GSK-3β) is a key enzyme in glycogen synthesis. The dysregulation of this kinase contributes to many disorders in neurophysiology, especially the formation of senile plaques and neurofibrillary tangles. In this review, we conclude the effects of GSK-3β on the development of AD and the current studies of GSK-3β inhibitors in the treatment of AD.

Key words: Glycogen synthase kinase-3, Alzheimer disease, Glycogen synthase kinase-3β inhibitors

京ICP 备07035254号-20
Copyright © Chinese Journal of Diagnostics(Electronic Edition), All Rights Reserved.
Tel: 0537-3616261 E-mail: zhzdxzz@126.com
Powered by Beijing Magtech Co. Ltd