Chinese experts′ consensus on multidisciplinary diagnosis and treatment of globus sensation

doi:10.3877/cma.j.issn.2095-655X.2020.04.001

Abstract

Abstract:

Globus sensation has a high incidence, accompanied by anxiety, depression and sleep disturbance, which is a commonly encountered psychosomatic disorder in clinic. Its diagnosis and treatment need multidisciplinary participation. The main treatments include anti-anxiety and anti-depression therapy, cognitive behavioral therapy, Chinese medicine, and so on. But so far, there is no recognized multidisciplinary consensus on diagnosis and treatment of globus sensation at home and abroad. This consensus is based on community epidemiological surveys and clinical registration studies, which is a positive guidance for clinicians in the diagnosis and treatment of globus sensation.

Key words: Globus sensation, Functional gastrointestinal disorders, Diagnosis, Treatment

Chinese Society of Behavioral Medicine. Chinese experts′ consensus on multidisciplinary diagnosis and treatment of globus sensation[J]. Chinese Journal of Diagnostics(Electronic Edition), 2020, 08(04): 217-222.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhzdxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-655X.2020.04.001

https://zhzdxdzzz.cma-cmc.com.cn/EN/Y2020/V08/I04/217

Figures/Tables 1

References 33

[1]	Drossman DA.Functional fastrointestinal disorders：history，pathophysiology，clinical features and Rome IV[J]．Gastroenterology，2016，150(6): 1262-1279.
[2]	Harar RP, Kumar S, Saeed MA, et al. Management of globus pharyngeus：review of 699 cases[J]．J Laryngol Otol，2004，118(7): 522-527.
[3]	Thompson WG, Heaton KW.Heartburn and globus in apparently healthy people[J]．Can Med Assoc J，1982，126(1): 46-48.
[4]	Moloy PJ, Charter R．The globus symptom.Incidence，therapeutic response，and age and sex relationships[J]．Arch Otolaryngol，1982，108(11): 740-744.
[5]	Rasmussen ER, Schnack DT, Ravn AT.A prospective cohort study of 122 adult patients presenting to an otolaryngologist's office with globus pharyngeus[J]．Clin Otolaryngol，2018，43(3): 854-860.
[6]	赵寒冰，蔡厚达，贾林，等．癔球症患者的临床发病学-精神心理特征：附559例病例分析[J]．现代消化及介入诊疗，2018，23(3): 293-296.
[7]	唐见，贾林，蔡厚达，等．广州地区人群癔球症的发病学特征及域乡差异[J]．中华行为医学与脑科学杂志，2016，25(6): 537-541.
[8]	Tang B, Cai HD, Xie HL，et al.Epidemiology of globus symptoms and associated psychological factors in China[J]．J Dig Dis，2016，17(5): 319-324.
[9]	Tawil J, Fass R．Globus：current concepts and dilemmas[J]．J Clin Gastroenterol，2018，52(10): 845-852.
[10]	Deary IJ, Wilson JA, Kelly SW.Globus pharyngis，personality，and psychological distress in the general population[J]．Psychosomatics，1995，36(6): 570-577.
[11]	Harris MB, Deary IJ, Wilson JA. Life events and difficulties in relation to the onset of globus pharyngis[J]．J Psychosom Res，1996，40(6): 603-615.
[12]	Tang B, Jia L, Liu J, et al. Clinical-psychological characteristics of refractory globus patients in China[J]．Dig Liver Dis，2016，48(4): 381-384.
[13]	Corso MJ, Pursnani KG, Mohiuddin MA，et al.Globus sensation is associated with hypertensive upper esophageal sphincter but not with gastroesophageal reflux[J]．Dig Dis Sci，1998，43(7): 1513-1517.
[14]	Peng L, Patel A, Kushnir V，et al.Assessment of upper esophageal sphincter function on high-resolution manometry：identification of predictors of globus symptoms[J]．J Clin Gastroenterol，2015，49(2): 95-100.
[15]	Halum SL, Butler SG, Koufman JA，et al.Treatment of globus by upper esophageal sphincter injection with botulinum A toxin[J]．Ear Nose Throat J，2005，84(2): 74.
[16]	Cook IJ, Dent J, Collins SM.Upper esophageal sphincter tone and reactivity to stress in patients with a history of globus sensation[J]．Dig Dis Sci，1989，34(5): 672-676.
[17]	Nevalainen P, Walamies M, Kruuna O, et al. Supragastric belch may be related to globus symptom—a prospective clinical study[J]．Neurogastroenterol Motil，2016，28(5): 680-686.
[18]	陈冬云，贾林．癔球症患者食管上括约肌压力分型及其严重程度的影响因素[J/CD]．中华诊断学电子杂志，2016，4(3): 153-156.
[19]	Zhou W, Jia L, Chen D，et al.The effects of paroxetine and amitriptyline on the upper esophageal sphincter (UES) pressure and its natural history in globus pharyngeus[J]．Dig Liver Dis，2017，49(7): 757-763.
[20]	Chen CL, Szczesniak MM, Cook IJ. Evidence for oesophageal visceral hypersensitivity and aberrant symptom referral in patients with globus[J]．Neurogastroenterol Motil，2009，21(11): 1142-1196.
[21]	Kiebles JL, Kwiatek MA, Pandolfino JE, et al. Do patients with globus sensation respond to hypnotically assisted relaxation therapy? a case series report[J]．Dis Esophagus，2010，23(7): 545-553.
[22]	Khalil HS, Bridger MW, Hilton-Pierce M，et al.The use of speech therapy in the treatment of globus pharyngeus patients.A randomised controlled trial[J]．Rev Laryngol Otol Rhinol (Bord)，2003，124(3): 187-190.
[23]	Deary IJ, Wilson JA.Problems in treating globus pharyngis[J]．Clin Otolaryngol Allied Sci，1994，19(1): 55-60.
[24]	You L．Effect of low-dose amitriptyline on globus pharyngeus and its side effects[J]．World J Gastroenterol，2013，19(42): 7455-7460.
[25]	Chen DY, Jia L, Gu X，et al.Comparison of paroxetine and amitriptyline in the treatment of refractory globus pharyngeus[J]．Dig Liver Dis，2016，48(9): 1012-1017.
[26]	游乐卿，刘静，贾林．小剂量阿米替林治疗癔球症的综合疗效、副反应及其耗费[J]．国际医药卫生导报，2013，19(20): 3104-3108.
[27]	Morgan V, Pickens D, Gautam S，et al.Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome[J]．Gut，2005，54(5): 601-607.
[28]	Huang W, Jiang SM, Jia L，et al.Effect of amitriptyline on gastrointestinal function and brain-gut peptides：a double-blind trial[J]．World J Gastroenterol，2013，19(26): 4214-4220.
[29]	Rahimi R, Nikfar S, Rezaie A，et al.Efficacy of tricyclic antidepressants in irritable bowel syndrome：a meta-analysis[J]．World J Gastroenterol，2009，15(13): 1548-1553.
[30]	江舒曼，贾林，李伟冬，等．半夏厚朴清心汤联合经皮穴位电刺激治疗癔球症的临床疗效[J]．广东医学，2018，39(20): 3119-3122.
[31]	Zhou W, Deng Q, Jia L, et al. Acute effect of transcutaneous electroacupuncture on globus pharyngeus：a randomized，single-blind，crossover trial[J]．Front Med (Lausanne)，2020(7): 179.
[32]	何梓健，贾林，邓祺，等．癔球症患者临床精神心理学特征及少商穴经皮电刺激治疗的疗效评价[J/CD]．中华诊断学电子杂志，2020，8(2): 130-134.
[33]	Timon C, O′Dwyer T, Cagney D，et al.Globus pharyngeus：long-term follow-up and prognostic factors[J]．Ann Otol Rhinol Laryngol，1991，100(5 Pt 1): 351-354.

Please choose a citation manager

Content to export