Advances in the study of lactate dehydrogenase A in breast cancer diagnosis and treatment

doi:10.3877/cma.j.issn.2095-655X.2024.02.012

Abstract

Abstract:

Breast cancer is a highly heterogeneous malignant tumor, and the existing means for early breast cancer diagnosis remain limited. Lactate dehydrogenase A (LDHA) is a key enzyme involved in glycolysis in tumor cells, which is associated with malignant progression such as tumor growth and proliferation, immune escape, and invasion and metastasis. It has been reported that LDHA is abnormally highly expressed in breast cancer. However, the specific reasons why LDHA promotes breast cancer progression are not fully understood. Exploring the molecular mechanism between LDHA and breast cancer progression is of great value to the future exploration of LDHA as a new diagnostic marker and the development of new anti-tumor drugs. In this paper, the author summarizes the research progress of LDHA in breast cancer diagnosis and treatment based on the latest reports from home and abroad.

Key words: Lactate dehydrogenase A, Breast neoplasms, Glycolysis, Warburg effect

Yifei Li, Wenran Li, Huan Liu. Advances in the study of lactate dehydrogenase A in breast cancer diagnosis and treatment[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(02): 128-132.

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