The idea of mind-body integration existed in practice of traditional Chinese medicine (TCM) at the very beginning, and psychosomatic medicine as a special term was from western world.Discussion about psychosomatic medicine was basically limited within philosophy and psychiatrics before 1980s.It did not find extensive application in practice of non-psychiatric medicine to manage psycho-social factors in medical setting until 1980s.Brife history and worldwide development of psychosomatic medicine, the diversification of its definition, its incorporation into clinical practice and the development and expection of its incorporation into clinical gastroenterology will be discussion in the article.