The relationship between the serum ACA-IgG, IL-17 and hsCRP concentration and middle cerebral artery atherosclerotic stenosis of young adults

doi:10.3877/cma.j.issn.2095-655X.2017.01.014

Abstract

Abstract:

Objective

To explore the relationship between the serum anticardiolipin antibody-immune globulin G (ACA-IgG), interleukin-17 (IL-17) and high-sensitivity C-reactive protein (hsCRP) concentration and intracerebral artery stenosis middle cerebral artery atherosclerotic stenosis.

Methods

By digital subtraction angiography (DSA), 78 patients with ischemic cerebrovascular disease were enrolled and divided into a stenosis-free group(21 cases), mild-stenosis group (n=22), moderate-stenosis group (n=18), and severe-stenosis group (n=17). The level of serum ACA-IgG, IL-17 and hsCRP were detected.

Results

The levels of serum ACA-IgG in the stenosis-free group, mild, moderate and severe stenosis groups were (25.53±6.23)kU/L, (36.14±6.67)kU/L, (47.75±8.31)kU/L and (62.41±11.26)kU/L respectively.The levels of serum IL-17 were (35.54±11.32)ng/L, (57.62±19.06)ng/L, (64.05±28.67)ng/L and (78.36±25.01)ng/L respectively.The level of serum hsCRP were (2.06±1.53)mg/L, (4.23±1.17)mg/L, (5.30±1.34)mg/L and (6.72±2.01)mg/L respectively.Compared with stenosis-free group, the levels of serum ACA-IgG and IL-17 were significantly increased in the mild, moderate and severe stenosis groups(all P<0.05). Logistic regression analysis showed that the odds ratio (OR) of hyper ACA-IgG and IL-17 for intracerebral artery stenosis were 1.624 and 1.235, respectively.

Conclusion

ACA-IgG and IL-17 may play an important role in middle cerebral artery atherosclerotic stenosis of young adult.

Key words: Stroke, Middle cerebral artery, Anticardiolipin antibody, Interleukin-17

Xianbo Zhuang, Weifei Wang, Guangzhen Shan, Tuanzhi Chen, Guisheng Jiang, Xiafeng Yang. The relationship between the serum ACA-IgG, IL-17 and hsCRP concentration and middle cerebral artery atherosclerotic stenosis of young adults[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(01): 51-54.

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References 19

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组别	例数	高血压	糖尿病	高脂血症	饮酒	吸烟
无狭窄组	21	8(38.1)	4(19.0)	9(42.8)	6(28.6)	8(38.1)
轻度狭窄组	22	14(63.6)^a	9(40.1)^d	8(36.4)	7(31.8)	9(40.9)
中度狭窄组	18	12(66.7)^b	10(55.6)^e	9(50.0)	6(33.3)	8(44.4)
重度狭窄组	17	12(70.6)^c	11(64.7)^fg	8(47.1)	7(41.2)	8(47.1)

组别	例数	高血压	糖尿病	高脂血症	饮酒	吸烟
无狭窄组	21	8(38.1)	4(19.0)	9(42.8)	6(28.6)	8(38.1)
轻度狭窄组	22	14(63.6)^a	9(40.1)^d	8(36.4)	7(31.8)	9(40.9)
中度狭窄组	18	12(66.7)^b	10(55.6)^e	9(50.0)	6(33.3)	8(44.4)
重度狭窄组	17	12(70.6)^c	11(64.7)^fg	8(47.1)	7(41.2)	8(47.1)

组别	例数	ACA-IgG(kU/L)	IL-17(ng/L)	hsCRP(mg/L)
无狭窄组	21	25.53± 6.23	35.54±11.32	2.06±1.53
轻度狭窄组	22	36.14± 6.67^a	57.62±19.06^a	4.23±1.17^a
中度狭窄组	18	47.75± 8.31^a	64.05±28.67^a	5.30±1.34^a
重度狭窄组	17	62.41±11.26^ab	78.36±25.01^ab	6.72±2.01^a
F值	?	15.36	10.16	9.58
P值	?	<0.01	<0.01	<0.01

组别	例数	ACA-IgG(kU/L)	IL-17(ng/L)	hsCRP(mg/L)
无狭窄组	21	25.53± 6.23	35.54±11.32	2.06±1.53
轻度狭窄组	22	36.14± 6.67^a	57.62±19.06^a	4.23±1.17^a
中度狭窄组	18	47.75± 8.31^a	64.05±28.67^a	5.30±1.34^a
重度狭窄组	17	62.41±11.26^ab	78.36±25.01^ab	6.72±2.01^a
F值	?	15.36	10.16	9.58
P值	?	<0.01	<0.01	<0.01

变量	B值	Wald值	P值	OR值	95%CI
年龄	2.534	1.032	0.265	1.923	1.541～2.230
高血压	0.964	2.153	0.064	2.430	2.016～4.252
糖尿病	0.842	9.355	0.000	2.736	1.422～4.315
高脂血症	1.921	2.132	0.071	3.208	1.836～2.524
吸烟	1.145	2.046	0.074	3.541	1.273～4.328
饮酒	0.820	1.634	0.132	1.732	1.041～1.925
ACA－IgG	1.416	4.351	0.032	1.624	2.103～3.742
IL－17	0.871	6.738	0.013	1.235	1.205～2.603
hsCRP	0.653	2.163	0.061	0.924	0.432～2.205
常数项	1.215	2.161	0.062	0.842	……

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