Abstract:
Objective To investigate the predictive value of semi-quantitative parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with human epidermal growth factor receptor 2 (Her-2) in breast cancer.
Methods From January 2016 to December 2019, a total of 65 patients with invasive breast cancer who underwent DCE-MRI in the Imaging Department of Suzhou Hospital Affiliated to Nanjing Medical University and confirmed by pathology were selected. Her-2 expression was detected in all patients by immunohistochemical method, and the patients were divided into Her-2 positive group and Her-2 negative group. Semi-quantitative parameters including rate of contrast enhancement for contrast agent inflow (W-in), rate of contrast decay for contrast agent outflow (W-out), time-to-peak enhancement after contrast agent injection (TTP), positive enhancement integral (PEI) and time-signal intensity curve (TIC) were compared between the two groups. Further, receiver operating characteristic (ROC) curve was used to analyze the effectiveness of each parameter in the diagnosis of positive Her-2.
Results Among the 65 cases, immunohistochemical staining showed Her-2 positive in 31 cases and Her-2 negative in 34 cases. Compared with Her-2 negative group [1.49±0.21, (0.71±0.12)min], the values of W-in (1.25±0.19) and TTP [(0.55±0.10)min] in the Her-2 positive group were significant decreased (t=-4.99, -5.46, all P<0.01), while the value of W-out (0.28±0.77) in the Her-2 positive group was significant increased compared to Her-2 negative group (0.20±0.08) (t=4.54, P<0.01). However, there was no significant difference in PEI values (145.12±15.81, 141.54±17.69) between the two groups (t=0.85, P>0.05). In addition, TIC types of the two groups were mainly type Ⅱ (11 cases, 15 cases) or Ⅲ (17 cases, 16 cases), and there was no significant difference (χ2=0.42, P>0.05). The area under the curve (AUC) of semi-quantitative parameters combination of DCE-MRI (AUC=0.890) was significant higher than that of single W-in, W-out, TTP, PEI(AUC=0.813, 0.802, 0.829, 0.589) respectively, and the differences of AUC were statistically significant (Z=3.39, 5.24, 3.08, 7.34, all P<0.05).
Conclusion Semi-quantitative parameters of DCE-MRI have a certain clinical value in the determination of breast cancer with Her-2 positive, and they can provide a reference for clinical treatment.
Key words:
Magnetic resonance imaging,
Breast cancer,
Human epidermal growth factor receptor 2
You Meng, Fan Zhang, Chenlu Liu, Yuying Shen, Qing Cai, Shuangqing Chen. The predictive value of semi-quantitative parameters of dynamic contrast enhanced magnetic resonance imaging with human epidermal growth factor receptor 2 in breast cancer[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(01): 40-45.