The esophageal motility characteristics and levels of brain-gut peptide in patients with refractory globus

doi:10.3877/cma.j.issn.2095-655X.2016.03.002

Abstract

Abstract:

Objective

To compare the esophageal motility and the levels of brain-gut peptide between refractory globus patients and non-refractory globus patients.

Methods

All subjects underwent high-resolution manometry (HRM) and were detected the levels of brain-gut peptide, which were compared the differences between refractory globus patients and non-refractory globus patients.

Results

Refractory globus patients had higher upper esophageal sphincter (UES) resting press [(94.97±42.08)mmHg] compared with non-refractory globus patients [(73.91±23.47)mmHg, t=2.359, P<0.05]. There were no statistical differences in UES residual pressure[(12.44±8.31)mmHg, (12.66±8.12)mmHg], UES length[(22.72±10.13)mm, (19.71±7.85)mm], CFV[(5.47±1.39)cm/s, (5.24±1.40)cm/s], DL[(6.59±1.29)s, (6.78±1.10)s], LES[(22.63±10.17)mmHg, (19.56±7.63)mmHg] between refractory globus patients and non-refractory globus patients (t=0.528, 0.471, 0.725, 0.736, 0.486; P>0.05). The level of NPY was lower in refractory globus patients [(626.26±16.60)ng/L] than that in non-refractory globus patients [(641.35±17.45)ng/L (t=2.528, P<0.05)], but the level of SP was higher in refractory globus patients [(2386.96±372.68)ng/L] than that in non-refractory globus patients [(1607.77±345.91)ng/L], the difference was statistically different (t=3.728, P<0.05). And no statistical difference was found in calcitonin gene-related peptide (CGRP) between refractory globus patients and non-refractory globus patients (t=0.752, P>0.05).

Conclusion

Compared with non-refractory globus patients, refractory globus patients have higher UES resting pressure, higher level of SP and lower level of NPY.

Key words: Globus, Esophageal sphincter, upper, Calcitonin gene-related peptide, Neuropeptide Y, Substance P

Yao Liu, Lin Jia. The esophageal motility characteristics and levels of brain-gut peptide in patients with refractory globus[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(03): 149-152.

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References 19

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组别	例数	性别(例，%)		年龄(岁，±s)	吸烟(例，%)		饮酒(例，%)
组别	例数	女	男	年龄(岁，±s)	是	否	是	否
难治性癔球症	43	27(62.79)	16(37.21)	46.76±12.92	7(16.28)	36(83.72)	8(18.60)	35(81.40)
非难治性癔球症	77	48(62.34)	29(37.66)	44.94±13.07	13(16.88)	64(83.12)	15(19.48)	62(80.52)
统计量	?	χ²＝0.002		t＝1.593	χ²＝0.007		χ²＝0.014
P值	?	0.961		0.497	0.932		0.907

组别	例数	性别(例，%)		年龄(岁，±s)	吸烟(例，%)		饮酒(例，%)
组别	例数	女	男	年龄(岁，±s)	是	否	是	否
难治性癔球症	43	27(62.79)	16(37.21)	46.76±12.92	7(16.28)	36(83.72)	8(18.60)	35(81.40)
非难治性癔球症	77	48(62.34)	29(37.66)	44.94±13.07	13(16.88)	64(83.12)	15(19.48)	62(80.52)
统计量	?	χ²＝0.002		t＝1.593	χ²＝0.007		χ²＝0.014
P值	?	0.961		0.497	0.932		0.907

组别	例数	UES静息压(mmHg)	UES残余压(mmHg)	UES长度(mm)	CFV(cm/s)	DL(s)	LES静息压(mmHg)
难治性癔球症	43	94.97±42.08	12.44±8.31	22.72±10.13	5.47±1.39	6.59±1.29	22.63±10.17
非难治性癔球症	77	73.91±23.47	12.66±8.12	19.71± 7.85	5.24±1.40	6.78±1.10	19.56± 7.63
t值	?	2.359	0.528	0.471	0.725	0.736	0.486
P值	?	0.010	0.897	0.130	0.440	0.426	0.103

组别	例数	UES静息压(mmHg)	UES残余压(mmHg)	UES长度(mm)	CFV(cm/s)	DL(s)	LES静息压(mmHg)
难治性癔球症	43	94.97±42.08	12.44±8.31	22.72±10.13	5.47±1.39	6.59±1.29	22.63±10.17
非难治性癔球症	77	73.91±23.47	12.66±8.12	19.71± 7.85	5.24±1.40	6.78±1.10	19.56± 7.63
t值	?	2.359	0.528	0.471	0.725	0.736	0.486
P值	?	0.010	0.897	0.130	0.440	0.426	0.103

组别	例数	CGRP	NPY	SP
难治性癔球症	37	236.17±76.85	626.26±16.60	2386.90±372.68
非难治性癔球症	25	229.35±57.52	641.35±17.45	1607.00±345.91
t值	?	0.752	2.528	3.728
P值	?	0.692	0.001	0.001

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