The types of upper esophageal sphincter pressure and influencing factors in patients with globus pharyngeus

doi:10.3877/cma.j.issn.2095-655X.2016.03.003

Abstract

Abstract:

Objective

To explore the types of upper esophageal sphincter (UES) pressure and influencing factors in patients with globus pharyngeus.

Methods

UES resting pressure of 120 patients with globus pharyngeus were taken by high resolution manometry (HRM), and all patients were evaluated by Glasgow Edinburgh Throat Scale (GETS), Pittsburgh Sleep Quality Index (PSQI) and hamilton Rating Scale Anxiety/Depression(HAMA/HAMD). According to the UES resting pressure, the 120 patients were divided into hypertensive UES group and non-hypertensive UES group.

Results

24.2% (29/120) of globus pharyngeus patients had high UES resting pressure, while 33.3% (40/120) of globus phyaryngeus patients had high UES residual pressure. Hypertensive UES patients had longer symptom duration [(42.17±50.11)months, (20.67±17.07)months], more severe symptom [(11.79±3.49)points, (7.81±2.12)points], higher UES resting pressure [(131.38±22.38)mmHg, (66.83±16.98)mmHg], higher HAMA scores [(13.59±2.84)points, (8.08±1.46)points], compared with non-hypertensive UES group (t=4.175, 3.957, 4.126, 3.382; P<0.05). The severity of globus pharyngeus symptoms was associated with UES residual pressure, UES resting pressure, HAMA scores. Multiple linear regression analysis showed that UES residual pressure, UES resting pressure, HAMA scores were influencing factors of globus symptoms.

Conclusions

Hypertensive UES is not rare among globus patients. Hypertensive UES patients have longer symptom duration, more severe symptom, higher UES resting pressure, higher HAMA scores. The severity of globus pharyngeus symptoms is associated with symptom duration, UES residual pressure, UES resting pressure, HAMA scores.

Key words: Globus pharyngeus, Esophageal sphincter, upper, High resolution manometry

Dongyun Chen, Lin Jia. The types of upper esophageal sphincter pressure and influencing factors in patients with globus pharyngeus[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(03): 153-156.

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Figures/Tables 3

References 21

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项目	非高压组(n＝91)	高压组(n＝29)	统计量	P值
性别(例，男/女)	35/56	10/19	χ²＝0.061	0.827
年龄(岁，±s)	45.43±13.10	45.50±12.80	t＝0.382	0.970
病程(月，±s)	20.67±17.07	42.17±50.11	t＝4.175	0.000
GETS(分，±s)	7.81±2.12	11.79±3.49	t＝3.957	0.003
UES静息压(mmHg，±s)	66.83±16.98	131.38±22.38	t＝4.126	0.000
UES残余压(mmHg，±s)	12.41±8.54	13.70±10.72	t＝0.629	0.507
LES静息压(mmHg，±s)	19.16±8.75	20.22±8.72	t＝0.821	0.569
PSQI(分，±s)	7.59±4.36	9.03±4.70	t＝0.709	0.538
HAMA(分，±s)	8.08±1.46	13.59±2.84	t＝3.382	0.001
HAMD(分，±s)	7.36±3.93	7.52±4.74	t＝1.754	0.088

项目	非高压组(n＝91)	高压组(n＝29)	统计量	P值
性别(例，男/女)	35/56	10/19	χ²＝0.061	0.827
年龄(岁，±s)	45.43±13.10	45.50±12.80	t＝0.382	0.970
病程(月，±s)	20.67±17.07	42.17±50.11	t＝4.175	0.000
GETS(分，±s)	7.81±2.12	11.79±3.49	t＝3.957	0.003
UES静息压(mmHg，±s)	66.83±16.98	131.38±22.38	t＝4.126	0.000
UES残余压(mmHg，±s)	12.41±8.54	13.70±10.72	t＝0.629	0.507
LES静息压(mmHg，±s)	19.16±8.75	20.22±8.72	t＝0.821	0.569
PSQI(分，±s)	7.59±4.36	9.03±4.70	t＝0.709	0.538
HAMA(分，±s)	8.08±1.46	13.59±2.84	t＝3.382	0.001
HAMD(分，±s)	7.36±3.93	7.52±4.74	t＝1.754	0.088

变量	r值	P值
UES静息压	0.617	0.000
UES残余压	0.265	0.003
LES静息压	0.012	0.899
PSQI评分	0.082	0.372
HAMA评分	0.531	0.000
HAMD评分	0.105	0.253

变量	r值	P值
UES静息压	0.617	0.000
UES残余压	0.265	0.003
LES静息压	0.012	0.899
PSQI评分	0.082	0.372
HAMA评分	0.531	0.000
HAMD评分	0.105	0.253

因变量	预测变量	非标准化回归数		标准化偏回归数	t值	P值	R ²值	F值	P值
因变量	预测变量	β	标准误	Beta	t值	P值	R ²值	F值	P值
癔球症症状评分	常量	2.813	0.747	?	3.765	0.000	0.424	28.506	0.000
?	食管上括约肌静息压	0.040	0.010	0.436	4.166	0.000	?	?	?
?	食管上括约肌残余压	0.059	0.024	0.176	2.443	0.016	?	?	?
?	抑郁量表评分	0.206	0.104	0.205	1.985	0.049	?	?	?

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