Research progress of regulatory B cells in multiple myeloma

doi:10.3877/cma.j.issn.2095-655X.2024.02.013

Abstract

Abstract:

Multiple myeloma (MM) is a malignant proliferative disorder of bone marrow plasma cells. Suppressive immune microenvironment is one of the important mechanisms for the impaired anti-tumor immune surveillance in MM patients, leading to the immune escape of malignant plasma cells. Regulatory immune cells are considered to be an important part of the suppressive immune microenvironment, and regulatory B cells (Bregs), as a special type of B cells discovered in recent years, can exert immunosuppressive effects mainly through the secretion of various inhibitory soluble cytokines and direct contact with cells. The increased proportion of Bregs in the bone marrow microenvironment of MM may participate in the formation of immunosuppressive bone marrow microenvironment by screting IL-10 and inhibiting the function of natural killer cells, thereby affecting the therapeutic response and prognosis of MM, so Bregs is expected to become a potential immunotherapeutic target of MM. This article mainly reviews the phenotype, source, immunomodulatory mechanisms and research progress of Bregs in MM.

Key words: B-lymphocytes, regulatory, Multiple myeloma, Tumor microenvironment, Immunoregulation

Tian Lu, Daoping Sun. Research progress of regulatory B cells in multiple myeloma[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(02): 133-137.

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