Terrorist attacks are special non-war violence behaviors which are made by individuals or organizations for some political or social purposes.Among which, explosive terrorist attack is the most common type.This article has described the characteristics of urban explosion and challenges for its medical rescue, reviewed the major medical rescue experience in Boston bombings, and suggested the following ideas which are helpful for dealing with urban explosion terrorist events: (1)Actively promote the standardization of trauma treat training.(2)Accelerate the construction of trauma treat centers.(3)Carry out combat-like emergency medical rescue training.(4)Provide good medical support for major emergency events.(5)Continuously improve emergency medical rescue based on summarizing the previous shortcomings.