The variation of weight for age Z score in preterm infants with extrauterine growth restriction

doi:10.3877/cma.j.issn.2095-655X.2016.02.011

Abstract

Abstract:

Objective

To explore the variation of weight for age Z score in preterm infants with extrauterine growth restriction (EUGR)during the hospitalization.

Methods

Data of the premature infant from the Neonatal intensive care unit of Huai′an Maternity and Child Healthcare Hospital from December 1, 2010 to November 30, 2013 were collected retrospectively.The criteria for enrollment were gestational age <32 weeks, within the first 24 hours of life and survived when discharged, and hospitalization period ≥2 weeks.With the criteria, all of the premature infants were divided into extrauterine growth restriction (EUGR) group and non-EUGR group.And then, WAZ score count of each specific group was described to observe their growth situation during the hospitalization.

Results

Preterm infants with EUGR were 122 cases, the incidence of EUGR assessed by weight was 40.7%.WAZ scores of the EUGR group and non-EUGR group were almost negative. Z score of the EUGR group was lower than that of the control group.All of the WAZ scores were showed significant difference (Z=10.72, 11.00, 11.47, 10.72, 8.91, 14.42 respectively, P<0.05) between the EUGR and non-EUGR group in each observing time, such as at birth (-0.83±0.37, -0.25±0.39), the 1st week (-1.16±0.35, -0.54±0.43), the 2nd week (-1.14±0.35, -0.46±0.46), the 3rd week (-1.21±0.34, -0.58±0.39), the 4th week (-1.35±0.41, -0.65±0.42), and at the discharged time(-1.68±0.38, -0.52±0.44).

Conclusions

The weight for age Z score in preterm infants with EUGR show a progressive decline.The WAZ score′ variation tendency have some clinical significance to prevent EUGR.

Key words: Fetal growth retardation, Infant, small for gestational age, Infant, premature, Weight for age Z score

Wenying Xu, Rong Wu. The variation of weight for age Z score in preterm infants with extrauterine growth restriction[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(02): 112-115.

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References 17

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因素\组别	EUGR组(n＝122)	非EUGR组(n＝178)	统计值	P值
女性(例，%)	55(45.1)	52(29.2)	χ²＝7.94	<0.05
宫外生长发育迟缓发生数(例，%)	15(12.3)	0(0)	χ²＝20.52	<0.05
极低体质量儿发生数(例，%)	75(61.5)	33(18.5)	χ²＝41.51	<0.05
出生体质量(g，±s)	1.43±0.21	1.70±0.20	t＝11.41	<0.05
出院体质量(g，±s)	2.12±0.21	2.23±0.21	t＝4.39	<0.05
出生胎龄(周，±s)	30.92±1.11	30.99±0.95	t＝0.58	>0.05
出院胎龄(周，±s)	36.65±1.41	34.95±1.24	t＝11.04	<0.05
出生年龄别体质量Z评分(±s)	－0.83±0.37	－0.25±0.39	t＝13.01	<0.05
出院年龄别体质量Z评分(±s)	－1.68±0.38	－0.52±0.44	t＝24.50	<0.05
住院天数(d，±s)	40.13±14.00	27.79±10.38	t＝8.30	<0.05
恢复出生体质量时间(d，±s)	9.52±3.68	8.85±3.42	t＝1.60	>0.05
体质量下降百分比(%，±s)	0.08±0.04	0.07±0.03	t＝2.90	<0.05
体质量增长速度(%，±s)	13.23±2.89	14.61±3.94	t＝3.52	<0.05
新生儿呼吸窘迫综合征(例，%)	46(37.7)	50(28.1)	χ²＝3.08	>0.05
新生儿坏死性小肠炎(例，%)	4(3.3)	2(1.1)	χ²＝0.79	>0.05
支气管肺发育不良(例，%)	10(8.2)	6(3.4)	χ²＝3.34	>0.05
动脉导管未闭(例，%)	11(9.0)	6(3.4)	χ²＝4.32	<0.05
晶状体后纤维增生性眼病(例，%)	7(5.7)	3(1.7)	χ²＝2.53	>0.05
窒息(例，%)	37(30.3)	47(26.4)	χ²＝0.55	>0.05
重度贫血(例，%)	19(15.6)	15(8.4)	χ²＝3.68	>0.05
机械通气数(例，%)	14(11.5)	13(7.3)	χ²＝1.17	>0.05

因素\组别	EUGR组(n＝122)	非EUGR组(n＝178)	统计值	P值
女性(例，%)	55(45.1)	52(29.2)	χ²＝7.94	<0.05
宫外生长发育迟缓发生数(例，%)	15(12.3)	0(0)	χ²＝20.52	<0.05
极低体质量儿发生数(例，%)	75(61.5)	33(18.5)	χ²＝41.51	<0.05
出生体质量(g，±s)	1.43±0.21	1.70±0.20	t＝11.41	<0.05
出院体质量(g，±s)	2.12±0.21	2.23±0.21	t＝4.39	<0.05
出生胎龄(周，±s)	30.92±1.11	30.99±0.95	t＝0.58	>0.05
出院胎龄(周，±s)	36.65±1.41	34.95±1.24	t＝11.04	<0.05
出生年龄别体质量Z评分(±s)	－0.83±0.37	－0.25±0.39	t＝13.01	<0.05
出院年龄别体质量Z评分(±s)	－1.68±0.38	－0.52±0.44	t＝24.50	<0.05
住院天数(d，±s)	40.13±14.00	27.79±10.38	t＝8.30	<0.05
恢复出生体质量时间(d，±s)	9.52±3.68	8.85±3.42	t＝1.60	>0.05
体质量下降百分比(%，±s)	0.08±0.04	0.07±0.03	t＝2.90	<0.05
体质量增长速度(%，±s)	13.23±2.89	14.61±3.94	t＝3.52	<0.05
新生儿呼吸窘迫综合征(例，%)	46(37.7)	50(28.1)	χ²＝3.08	>0.05
新生儿坏死性小肠炎(例，%)	4(3.3)	2(1.1)	χ²＝0.79	>0.05
支气管肺发育不良(例，%)	10(8.2)	6(3.4)	χ²＝3.34	>0.05
动脉导管未闭(例，%)	11(9.0)	6(3.4)	χ²＝4.32	<0.05
晶状体后纤维增生性眼病(例，%)	7(5.7)	3(1.7)	χ²＝2.53	>0.05
窒息(例，%)	37(30.3)	47(26.4)	χ²＝0.55	>0.05
重度贫血(例，%)	19(15.6)	15(8.4)	χ²＝3.68	>0.05
机械通气数(例，%)	14(11.5)	13(7.3)	χ²＝1.17	>0.05

组别	例数	入院时	1周	2周	3周	4周	出院时
宫外生长发育迟缓组	122	－0.83±0.37	－1.16±0.35	－1.14±0.35	－1.21±0.34	－1.35±0.41	－1.68±0.38
非宫外生长发育迟缓组	178	－0.25±0.39	－0.54±0.43	－0.46±0.46	－0.58±0.39	－0.65±0.42	－0.52±0.44
Z值	?	10.72	11.00	11.47	10.72	8.91	14.42
P值	?	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	入院时	1周	2周	3周	4周	出院时
宫外生长发育迟缓组	122	－0.83±0.37	－1.16±0.35	－1.14±0.35	－1.21±0.34	－1.35±0.41	－1.68±0.38
非宫外生长发育迟缓组	178	－0.25±0.39	－0.54±0.43	－0.46±0.46	－0.58±0.39	－0.65±0.42	－0.52±0.44
Z值	?	10.72	11.00	11.47	10.72	8.91	14.42
P值	?	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

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