The characters of electroencephalogram power in patients with Alzheimer disease

doi:10.3877/cma.j.issn.2095-655X.2015.01.010

Abstract

Abstract:

Objective

To study the change of electroencephalogram (EEG)power in patients with Alzheimer＇s disease(AD).

Methods

Thirty patients with AD and thirty healthy people were included.EEG was recorded during eyes-closed resting condition and was transformed to provide estimate for total power, absolute and relative power in delta, theta, alpha and beta activity frequency bands and δ+ θ/α+ β power radio.

Results

The power radio of δ+ θ/α+ β at Fp1, Fp2, F3, F4, C3, C4, P3, P4, O1, O2, F7, F8, T3, T4, T5, T6 in group AD[(1.18±0.27), (1.11±0.30), (1.05±0.36), (1.03±0.31), (1.00±0.33), (1.06±0.36), (0.99±0.38), (1.04±0.37), (0.97±0.37), (1.05±0.38), (0.99±0.33), (1.10±0.23), (0.91±0.28), (0.93±0.32), (1.00±0.40), (0.95±0.34)] were significantly higher than those in controls [(0.65±0.19), (0.63±0.09), (0.59±0.13), (0.55±0.11), (0.54±0.18), (0.49±0.12), (0.50±0.19), (0.47±0.13), (0.40±0.21), (0.40±0.14), (0.61±0.18), (0.59±0.14), (0.59±0.19), (0.54±0.16), (0.45±0.18), (0.50±0.18)] (P<0.05). The power of relative band theta at Fp1、Fp2、F3、F4、C3、C4、P3、P4、O1、O2、F7、F8、T3、T4、T5、T6 in group AD were significantly higher than those in controls (P<0.05). The power of relative band delta at Fp2, F4, C4, P3, P4, O1, O2, F7, F8, T5 in group AD were significantly higher than those in controls (P<0.05, P<0.01). The power of relative band alpha at Fp1, Fp2, F3, F4, C3, C4, P4, O1, O2, F7, F8, T3, T5, T6 in group AD were significantly lower than those in controls (P<0.05). The power of band theta at Fp1, Fp2, F8, T4, P4 in group AD were significantly higher than those in controls (P<0.05). The power of band alpha at Fp1, F3, O1, O2, F7 in group AD were significantly lower than those in controls (P<0.05). The power of band beta at P3, O1, O2, T5 in group AD were significantly lower than those in healthy people(P<0.05).

Conclusions

The quantiative electroencephalography (QEEG )of patients with Alzheimer disease is significantly different from controls, QEEG is helpful to diagnose AD.

Key words: Alzheimer disease, Electroencephalography, Fourier analysis

peng Yang, yang Yue, Xiaobao Zhou, yan Wang. The characters of electroencephalogram power in patients with Alzheimer disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2015, 03(01): 36-40.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhzdxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-655X.2015.01.010

https://zhzdxdzzz.cma-cmc.com.cn/EN/Y2015/V03/I01/36

Figures/Tables 6

References 21

[1]	Dauweis J,Vialatte F,Cichoski A. Diagnosis of Aizheimer′s disease from EEG signals：where are we standing？[J]. Curr Aizheimer Res, 2010, 7(6): 487-505.
[2]	杨志寅. 现代医学科学发展中的缺憾与思考[J/CD]. 中华诊断学电子杂志, 2013, 1(1): 1-7.
[3]	陈双庆,蔡庆,沈玉英, 等. 轻度认知功能损害患者扣带后回谷氨酸多体素氢质子磁共振波谱研究[J/CD]. 中华诊断学电子杂志, 2013, 1(1): 36-39.
[4]	Masdeu JC,Zubieta JL,Arbizu J. Neuroimaging as a marker of the onset and progression of Aizheimer, s disease[J]. J Neurol Sci, 2005, 236(1-2): 55-64.
[5]	蒋中标,王云华. 阿尔茨海默病的诊断进展[J]. 医学临床研究, 2011, 28(5): 944-946.
[6]	Czigler B,Csikós D,Hidasi Z, et al.Quantitative EEG in early Alzheimer′s disease patients-power spectrum and complexity features[J]. Internationnal Journal of Psychophysiology, 2008, 68(1): 75-80.
[7]	Xie L,Kang H,Xu Q, et al.Sleep drives metabolite clearance from the adult brain[J]. Science, 2013, 342(6156): 373-377.
[8]	Moretti DV,Paternicò D,Binetti G, et al.EEG upper/low alpha frequency power ratio and the impulsive disorders network in subjects with mild cognitive impairment[J]. Curr Alzheimer Res, 2014, 11(2): 192-199.
[9]	Julkunen P,Jauhiainen AM,Westerén-punnonen S, et al.Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer′s disease ：a pilot study[J]. J Neurosci Methods, 2008.172(2): 270-276.
[10]	Babiloni C,Frisoni G,Steriade M, et al.Frontal white matter vol-ume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease[J]. Clin Neurophysiol, 2006, 117(5): 1113-1129.
[11]	程灶火,蔡德亮,张荣, 等. 轻度认知损害和阿尔茨海默病患者脑电图改变与认知功能的关系[J]. 中华行为医学与脑科学杂志, 2009, 18 (12) : 1089-1092.
[12]	吕晓萍,吕洋,吕晓民, 等. 老年痴呆患者76例的脑电图分析[J]. 中国老年学杂志, 2011, 31(16): 3152-3153.
[13]	陈英,高鹏程,陶华英, 等. 基于频率特征的新老士兵脑电分析及其与抑郁量表评分的相关性研究[J]. 中华物理医学与康复杂志, 2013, 35(4): 282-285.
[14]	陈玉宝. 定量脑电图对阿尔茨海默病患者认知能力的评估作用[J]. 中国全科医学, 2012, 15(2): 209-210.
[15]	Gawel M,Zalewska E,Szmidt S E, et al.The value of quantitative EEG in differential diagnosis of Alzheimer＇s disease and subcortical vascular dementia[J]. Journal of the Neurological Sciences, 2009, 283(1-2): 127-133.
[16]	徐清,徐文炜,张玉琦, 等. 阿尔茨海默病与血管性痴呆定量脑电图波频差异研究[J]. 中国全科医学, 2013, 16(8): 2584-2588.
[17]	高永哲,章军建,吴光耀, 等. 阿尔茨海默病患者局部脑血流量及脑血管反应性研究[J]. 中风与神经疾病杂志, 2013, 30(2): 120-123.
[18]	Grunwald M,Busse F,Hensel A et al.Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia[J]. J Clin Neurophysiol, 2001, 18(2): 178-184.
[19]	张连春,陶华英. 阿尔茨海默病及轻度认知功能损害在不同状态下的脑电相对功率比研究[J]. 中华老年心脑血管病杂志, 2008, 10(10): 723-726.
[20]	冯锋,尚兰,曹文胜, 等. 阿尔茨海默病睡眠脑电图的研究进展[J]. 国际精神病学杂志, 2008, 35(1): 4-7.
[21]	王文娣,吕玉丹,牟静静, 等. 44例阿尔茨海默病患者认知功能与脑电图特点分析[J]. 中风与神经疾病杂志, 2014, 31(12): 1107-1110.

组别	例数	Fp1	Fp2	F3	F4	C3	C4	P3	P4
AD组	30	5.87±2.57	5.40±2.18	4.79±3.11	4.76±2.02	4.44±2.25	4.55±2.29	4.21±2.07	4.28±1.43
对照组	30	3.46±1.32	3.44±0.90	3.50±0.85	3.19±0.74	3.45±0.86	2.99±0.58	3.73±1.06	2.96±0.49
t值	?	2.20	2.19	1.06	1.93	1.09	1.75	0.55	2.34
P值	?	<0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05
组别	例数	O1	O2	F7	F8	T3	T4	T5	T6
AD组	30	4.37±1.54	4.34±1.04	3.29±1.02	3.69±1.59	3.18±1.32	2.98±0.73	3.36±1.62	2.98±1.05
对照组	30	3.59±1.28	3.42±1.29	2.31±0.45	2.24±0.59	2.12±0.27	2.04±0.44	2.37±1.09	2.20±0.71
t值	?	1.03	1.53	1.32	2.24	2.07	2.88	1.35	1.62
P值	?	>0.05	>0.05	>0.05	<0.05	>0.05	<0.05	>0.05	>0.05

组别	例数	Fp1	Fp2	F3	F4	C3	C4	P3	P4
AD组	30	5.87±2.57	5.40±2.18	4.79±3.11	4.76±2.02	4.44±2.25	4.55±2.29	4.21±2.07	4.28±1.43
对照组	30	3.46±1.32	3.44±0.90	3.50±0.85	3.19±0.74	3.45±0.86	2.99±0.58	3.73±1.06	2.96±0.49
t值	?	2.20	2.19	1.06	1.93	1.09	1.75	0.55	2.34
P值	?	<0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05
组别	例数	O1	O2	F7	F8	T3	T4	T5	T6
AD组	30	4.37±1.54	4.34±1.04	3.29±1.02	3.69±1.59	3.18±1.32	2.98±0.73	3.36±1.62	2.98±1.05
对照组	30	3.59±1.28	3.42±1.29	2.31±0.45	2.24±0.59	2.12±0.27	2.04±0.44	2.37±1.09	2.20±0.71
t值	?	1.03	1.53	1.32	2.24	2.07	2.88	1.35	1.62
P值	?	>0.05	>0.05	>0.05	<0.05	>0.05	<0.05	>0.05	>0.05

组别	例数	Fp1	Fp2	F3	F4	C3	C4	P3	P4
AD组	30	4.64±1.33	5.14±1.73	4.61±1.97	4.60±1.61	4.12±1.75	4.49±1.75	4.78±2.24	4.54±1.69
对照组	30	6.02±0.92	6.32±1.52	6.68±1.40	6.32±1.56	7.84±4.39	6.51±2.12	8.67±5.12	7.93±4.60
t值	?	2.25	1.35	2.29	2.02	2.08	1.94	1.84	1.57
P值	?	<0.05	>0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	O1	O2	F7	F8	T3	T4	T5	T6
AD组	30	5.59±3.47	5.13±2.24	3.1±1.16	3.56±1.92	3.10±1.00	3.12±1.33	3.71±1.70	3.19±1.37
对照组	30	12.9±7.59	12.9±7.59	4.45±0.78	4.18±1.31	4.30±1.68	3.91±1.07	6.08±2.47	5.45±2.65
t值	?	2.35	2.78	2.55	0.71	1.63	1.23	2.09	2.01
P值	?	<0.05	<0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	Fp1	Fp2	F3	F4	C3	C4	P3	P4
AD组	30	4.64±1.33	5.14±1.73	4.61±1.97	4.60±1.61	4.12±1.75	4.49±1.75	4.78±2.24	4.54±1.69
对照组	30	6.02±0.92	6.32±1.52	6.68±1.40	6.32±1.56	7.84±4.39	6.51±2.12	8.67±5.12	7.93±4.60
t值	?	2.25	1.35	2.29	2.02	2.08	1.94	1.84	1.57
P值	?	<0.05	>0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	O1	O2	F7	F8	T3	T4	T5	T6
AD组	30	5.59±3.47	5.13±2.24	3.1±1.16	3.56±1.92	3.10±1.00	3.12±1.33	3.71±1.70	3.19±1.37
对照组	30	12.9±7.59	12.9±7.59	4.45±0.78	4.18±1.31	4.30±1.68	3.91±1.07	6.08±2.47	5.45±2.65
t值	?	2.35	2.78	2.55	0.71	1.63	1.23	2.09	2.01
P值	?	<0.05	<0.05	<0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	Fp1	Fp2	F3	F4	C3	C4	P3	P4
AD组	30	0.24±0.05	0.25±0.04	0.22±0.06	0.21±0.04	0.20±0.07	0.22±0.05	0.21±0.07	0.22±0.06
对照组	30	0.19±0.04	0.20±0.03	0.17±0.03	0.16±0.04	0.15±0.04	0.14±0.05	0.14±0.05	0.14±0.05
t值	?	2.07	3.17	1.90	2.51	1.59	3.22	2.42	2.90
P值	?	>0.05	<0.01	>0.05	<0.05	>0.05	<0.01	<0.05	<0.05
组别	例数	O1	O2	F7	F8	T3	T4	T5	T6
AD组	30	0.21±0.07	0.23±0.06	0.22±0.04	0.23±0.04	0.19±0.05	0.19±0.05	0.20±0.07	0.20±0.06
对照组	30	0.13±0.05	0.11±0.03	0.18±0.03	0.18±0.03	0.17±0.05	0.17±0.06	0.14±0.04	0.15±0.04
t值	?	2.57	5.07	2.67	2.67	0.86	0.47	2.40	1.87
P值	?	<0.05	<0.01	<0.05	<0.05	>0.05	>0.05	<0.05	>0.05

Please choose a citation manager

Content to export